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Uncharacterized Protein C6orf201 is a protein that in humans is encoded by the C6orf201 (chromosome 6 open reading frame 201) gene.

C6orf201 is primarialy expressed in the testis. This gene also goes by the name dJ1013A10.5 and is located on the 6p25.2 region of the chromosome. The C6orf201 gene is conserved in mammals and some reptiles.

Gene
The gene is 51,558 base pairs long.

Aliases

 * 1) Chromosome 6 open reading frame 201
 * 2) C6orf201
 * 3) dJ1013A10.5
 * 4) MGC87625
 * 5) RP5-1013A10.5
 * 6) LOC404220

Locus
C6orf201 is located at 6p25.2 on the chromosome 6.

Names

 * 1) Protein MGC87625
 * 2) Hypothetical protein LOC404220
 * 3) OTTHUMP00000213693
 * 4) OTTHUMP00000213725

General porperties/features
The longest protein variant is 140 amino acids long, has a molecular weight of 16.2 kDa, and an isoelectric point of 10.88. C6orf201 is predicted to be a nuclear protein.

Protein interactions
C6orf201 interacts with SRPK1, TMEM106B , and APP.

Expression
C6orf201 is expressed in the testis and liver of humans. According to NCBI EST C6orf201 is also expressed in the testis of adult mice and rats. GEO microarray data also supports expression in the testis.

Conservation
C6orf201 is highly conserved in primates and is moderately conserved other mammals. There is some conservation in reptiles.

Paralogs
There are no paralogs or gene duplication events for C6orf201.

Homologous domains
C6orf201 belongs to DUF4523 (Pfam15023), a functionally uncharacterized family of proteins that is found in mammals.

Research Results
There was an article that found C6orf201 was one of the top 20 deregulated genes in monkeys that had been exposed to welding fumes for an extended period of time. Another article investigates gene expression after the use of a methylation inhibitor, C6orf201 being one of many genes investigated.