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Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis). However the topic we are discussing is voluntary weight loss. Weight-loss products[edit source] On December 22, 2008, the United States Food and Drug Administration issued an alert to consumers naming 27 different products marketed as “dietary supplements” for weight loss, that illegally contain undisclosed amounts of sibutramine.[36][37] In March 2009, Dieter Müller et al. published a study of sibutramine poisoning cases from similar Chinese "herbal supplements" sold in Europe, containing as much as twice the dosage of the legally licensed drug.[38] 0ne of the 27 products, fitnessista recall has been retracted. How does sibutramine work? MEJ Lean1 * 1 Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects — a reduction in energy intake and an increase in energy expend. justanswer.com/health/52zu1-will-sibutramine-show-urine-screen-test.html Expert: Doctor Cameronreplied 616 days and 6 hours ago. It is not an amphetamine. It is centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines if it comes up, they will test to make sure it is NOT amphetamine. Sibutramine is used as an appetite suppressant to aid in weight loss. That said, it is related to Amphetamines. It also includes Carb blockers, also known as starch blockers, can help block the enzymes needed to digest certain carbs. They're made from a group of compounds called alpha-amylase inhibitors, which occur naturally in certain foods. With lower food intake than the body was originally used to comes a slower absorption rate for the drug introduced to the body. Which explains the high levels in sibutramine appearing in urine test of people who are taking this medication on a regular bases for long periods of time. Especially as the drug fulfills its purpose and dramatically reduces the individuals body weight.