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THE FORMATION OF URINE
Homeostasis — also spelled homoeostasis or homœostasis — (from Greek: ὅμοιος, "hómoios", "similar",[1] and στάσις, stásis, "standing still"[2]) is the property of a system that regulates its internal environment and tends to maintain a stable, relatively constant condition of properties such as temperature or pH. It can be either an open or closed system. In simple terms, it is a process in which the body's internal environment is kept stable. It was defined by Claude Bernard and later by Walter Bradford Cannon in 1926,[3] 1929[4] and 1932.[5][6]Typically used to refer to a living organism, the concept of homeostasis was preceded by that of milieu intérieur, defined by Claude Bernard and published in 1865. Multiple dynamic equilibrium adjustment and regulation mechanisms make homeostasis possible.Homeostasis needs to be distinguished from simple dynamic equilibriums, which are not regulated, and steady states, which may be stable but sensitive to perturbations.Contents  [hide] 1 Biological1.1 Control mechanisms1.1.1 Positive feedback1.1.2 Negative feedback1.2 Homeostatic imbalance1.3 Varieties2 Ecological3 Biosphere4 Reactive5 Other fields5.1 Risk5.2 Stress6 Psychological7 See also8 References9 Further reading10 External linksBiological[edit source | editbeta]Further information: Human homeostasisWith regard to any given life system an organism may be a conformer or a regulator. Regulators try to maintain parameters at a constant level over possibly wide ambient environmental variations. Conformers allow the environment to determine parameters. For instance, endothermic animals (mammals and birds) maintain a constant body temperature, while ectothermic animals (almost all other organisms) exhibit wide body temperature variation.[citation needed]Behavioral adaptations allow ectothermic animals to exert some control over a given parameter. For instance, reptiles often rest on sun-heated rocks in the morning to raise their body temperature. Regulators are also responsive to external circumstances, however: if the same sun-baked boulder happens to host a ground squirrel, the animal's metabolism will adjust to the lesser need for internal heat production.[citation needed]Thermal image of a cold-blooded tarantula(ectothermic) on a warm-blooded human hand (endothermic).An advantage of homeostatic regulation is that it allows an organism to function effectively in a broad range of environmental conditions. For example, ectotherms tend to become sluggish at low temperatures, whereas a co-located endotherm may be fully active. That thermal stability comes at a price since an automatic regulation system requires additional energy. One reason snakes may eat only once a week is that they use much less energy to maintain homeostasis.[citation needed]Most homeostatic regulation is controlled by the release of hormones into the bloodstream. However, other regulatory processes rely on simplediffusion to maintain a balance.[citation needed]Homeostasis includes regulation of the pH of the blood at 7.365 (a measure of alkalinity and acidity). All animals also regulate their blood glucose, as well as the concentration of their blood. Mammals regulate their blood glucose with insulin and glucagon. The human body maintains glucose levels constant most of the day, even after a 24-hour fast. Even during long periods of fasting, glucose levels are reduced only very slightly.[7]Insulin, secreted by the beta cells of the pancreas, effectively transports glucose to the body's cells by instructing those cells to keep more of the glucose for their own use (see Dynamic equilibrium). If the glucose inside the cells is high, the cells will convert it to the insoluble glycogen to prevent the soluble glucose from interfering with cellular metabolism. Ultimately this lowers blood glucose levels, and insulin helps to preventhyperglycemia. When insulin is deficient or cells become resistant to it, diabetes occurs. Glucagon, secreted by the alpha cells of the pancreas, encourages cells to break down stored glycogen or convert non-carbohydrate carbon sources to glucose via gluconeogenesis, thus preventing hypoglycemia. The kidneys are used to remove excess water and ions from the blood. These are then expelled as urine. The kidneys perform a vital role in homeostatic regulation in mammals, removing excess water, salt, and urea from the blood. These are the body's main waste products.[citation needed]Another homeostatic regulation occurs in the gut. Homeostasis of the gut is not fully understood but it is believed that Toll-like receptor (TLR) expression profiles contribute to it. Intestinalepithelial cells exhibit important factors that contribute to homeostasis: 1) They have different cellular distribution of TLR's compared to the normal gut mucosa. An example of this is how TLR5(activated by flagellin) can redistribute to the basolateral membrane, which is the perfect place where flagellin can be detected.[8] 2) The enterocytes express high levels of TLR inhibitor Toll-interacting protein (TOLLIP). TOLLIP is a human gene that is a part of the innate immune system and is highest in a healthy gut; it correlates to luminal bacterial load.[8] 3) Surface enterocytes also express high levels of Interleukin-1 receptor (IL-1R) -containing inhibitory molecule. IL-1R are also referred to as single immunoglobulin IL-1R (SIGIRR). Animals deficient in this are more susceptible to induced colitis, implying that SIGIRR might possibly play a role in tuning mucosal tolerance towards commensal flora.[8] Nucleotide-binding oligomerisation domain containing 2 (NOD2) is suggested to have an effect on suppressing inflammatory cascades based on recent evidence.[8] It is believed to modulate signals transmitted through TLRs, TLR3, 4, and 9 specifically. Mutation of it has resulted in Crohn's disease. Excessive T-helper 1 responses to resident flora in the gut are controlled by inhibiting the controlling influence of regulatory T cells and tolerance-inducing dendritic cells.[citation needed]Sleep timing depends upon a balance between homeostatic sleep propensity, the need for sleep as a function of the amount of time elapsed since the last adequate sleep episode, and circadian rhythms that determine the ideal timing of a correctly structured and restorative sleep episode.[9]Control mechanisms[edit source | editbeta]All homeostatic control mechanisms have at least three interdependent components for the variable being regulated: The receptor is the sensing component that monitors and responds to changes in the environment. When the receptor senses a stimulus, it sends information to a "control center", the component that sets the range at which a variable is maintained. The control center determines an appropriate response to the stimulus. In most homeostatic mechanisms, the control center is the brain. The control center then sends signals to an effector, which can be muscles, organs or other structures that receive signals from the control center. After receiving the signal, a change occurs to correct the deviation by either enhancing it with positive feedback or depressing it with negative feedback.[10]Positive feedback[edit source | editbeta]Positive feedback is a mechanism by which an output is enhanced, such as protein levels. However, in order to avoid any fluctuation in the protein level, the mechanism is inhibited stochastically (I), therefore when the concentration of the activated protein (A) is past the threshold ([I]), the loop mechanism is activated and the concentration of A increases exponentially if d[A]=k [A]Positive feedback mechanisms are designed to accelerate or enhance the output created by a stimulus that has already been activated.Unlike negative feedback mechanisms that initiate to maintain or regulate physiological functions within a set and narrow range, the positive feedback mechanisms are designed to push levels out of normal ranges. To achieve this purpose, a series of events initiates a cascading process that builds to increase the effect of the stimulus. This process can be beneficial but is rarely used by the body due to risks of the acceleration's becoming uncontrollable.One positive feedback example event in the body is blood platelet accumulation, which, in turn, causes blood clotting in response to a break or tear in the lining of blood vessels. Another example is the release of oxytocin to intensify the contractions that take place during childbirth.[10]Negative feedback[edit source | editbeta]Negative feedback mechanisms consist of reducing the output or activity of any organ or system back to its normal range of functioning. A good example of this is regulating blood pressure. Blood vessels can sense resistance of blood flow against the walls when blood pressure increases. The blood vessels act as the receptors and they relay this message to the brain. The brain then sends a message to the heart and blood vessels, both of which are the effectors. The heart rate would decrease as the blood vessels increase in diameter (known as vasodilation). This change would cause the blood pressure to fall back to its normal range. The opposite would happen when blood pressure decreases, and would causevasoconstriction.Another important example is seen when the body is deprived of food. The body would then reset the metabolic set point to a lower than normal value. This would allow the body to continue to function, at a slower rate, even though the body is starving. Therefore, people who deprive themselves of food while trying to lose weight would find it easy to shed weight initially and much harder to lose more after. This is due to the body readjusting itself to a lower metabolic set point to allow the body to survive with its low supply of energy. Exercise can change this effect by increasing the metabolic demand.Another good example of negative feedback mechanism is temperature control. The hypothalamus, which monitors the body temperature, is capable of determining even the slightest variation of normal body temperature (37 degrees Celsius). Response to such variation could be stimulation of glands that produce sweat to reduce the temperature or signaling various muscles to shiver to increase body temperature.Both feedbacks are equally important for the healthy functioning of one's body. Complications can arise if any of the two feedbacks are affected or altered in any way.Homeostatic imbalance[edit source | editbeta]Many diseases are a result of disturbance of homeostasis, a condition known as homeostatic imbalance. As it ages, every organism will lose efficiency in its control systems. The inefficiencies gradually result in an unstable internal environment that increases the risk for illness. In addition, homeostatic imbalance is also responsible for the physical changes associated with aging. Even more serious than illness and other characteristics of aging is death. Heart failure has been seen where nominal negative feedback mechanisms become overwhelmed, and destructive positive feedback mechanisms then take over.[10]Diseases that result from a homeostatic imbalance include diabetes, dehydration, hypoglycemia, hyperglycemia, gout, and any disease caused by a toxin present in the bloodstream. All of these conditions result from the presence of an increased amount of a particular substance. In ideal circumstances, homeostatic control mechanisms should prevent this imbalance from occurring, but, in some people, the mechanisms do not work efficiently enough or the quantity of the substance exceeds the levels at which it can be managed. In these cases, medical intervention is necessary to restore the balance, or permanent damage to the organs may result.According to the following citation, every illness has aspects to it that are a result of lost homeostasis:"Just as we live in a constantly changing world, so do the cells and tissues survive in a constantly changing microenvironment. The 'normal' or 'physiologic' state then is achieved by adaptive responses to the ebb and flow of various stimuli permitting the cells and tissues to adapt and to live in harmony within their microenvironment. Thus, homeostasis is preserved. It is only when the stimuli become more severe, or the response of the organism breaks down, that disease results - a generalization as true for the whole organism as it is for the individual cell."[11]Varieties[edit source | editbeta]The Dynamic Energy Budget theory for metabolic organization delineates structure and (one or more) reserves in an organism. Its formulation is based on three forms of homeostasis:Strong homeostasis, whereas structure and reserve do not change in composition. Because the amount of reserve and structure can vary, this allows a particular change in the composition of the whole body (as explained by the Dynamic Energy Budget theory).Weak homeostasis, wherein the ratio of the amounts of reserve and structure becomes constant as long as food availability is constant, even when the organism grows. This means that the whole body composition is constant during growth in constant environments.Structural homeostasis, wherein the sub-individual structures grow in harmony with the whole individual; the relative proportions of the individuals remain constant.Ecological[edit source | editbeta]The concept of homeostasis is central to the topic of Ecological Stoichiometry. There it refers to the relationship between the chemical composition of an organism and the chemical composition of the nutrients it consumes. Stoichiometric homeostasis helps explain nutrient recycling and population dynamics.Historically, ecological succession was seen as having a stable end-stage called the climax (see Frederic Clements), sometimes referred to as the 'potential biodiversity' of a site, shaped primarily by the local climate. This idea has been largely abandoned by modern ecologists in favor of nonequilibrium ideas of how ecosystems function, as most natural ecosystems experience disturbance at a rate that makes a "climax" community unattainable.Only on small, isolated habitats known as ecological islands can the phenomenon be observed. One such case study is the island of Krakatoa after its major eruption in 1883: the established stable homeostasis of the previous forest climax ecosystem was destroyed, and all life was eliminated from the island. In the years after the eruption, Krakatoa went through a sequence of ecological changes in which successive groups of new plant or animal species followed one another, leading to increasing biodiversity and eventually culminating in a re-established climax community. This ecological succession on Krakatoa occurred in a number of stages; a sere is defined as "a stage in a sequence of events by which succession occurs". The complete chain of seres leading to a climax is called a prisere. In the case of Krakatoa, the island reached its climax community, with eight hundred different recorded species, in 1983, one hundred years after the eruption that cleared all life off the island. Evidence confirms that this number has been homeostatic for some time, with the introduction of new species rapidly leading to elimination of old ones. The evidence of Krakatoa, and other disturbed island ecosystems, has confirmed many principles of Island Biogeography, mimicking general principles of ecological succession albeit in a virtually closed system comprised almost exclusively of endemic species.Biosphere[edit source | editbeta]In the Gaia hypothesis, James Lovelock stated that the entire mass of living matter on Earth (or any planet with life) functions as a vast homeostatic superorganism that actively modifies its planetary environment to produce the environmental conditions necessary for its own survival. In this view, the entire planet maintains homeostasis. Whether this sort of system is present on Earth is still open to debate. However, some relatively simple homeostatic mechanisms are generally accepted. For example, it is sometimes claimed that when atmospheric carbon dioxide levels rise, certain plants are able to grow better and thus act to remove more carbon dioxide from the atmosphere[dubious – discuss]. However, warming has exacerbated droughts, making water the actuallimiting factor on land. When sunlight is plentiful and atmospheric temperature climbs, it has been claimed that the phytoplankton of the ocean surface waters may thrive and produce moredimethyl sulfide, DMS. The DMS molecules act as cloud condensation nuclei, which produce more clouds, and thus increase the atmospheric albedo, and this feeds back to lower the temperature of the atmosphere. However, rising sea temperature has stratified the oceans, separating warm, sunlit waters from cool, nutrient-rich waters. Thus, nutrients have become the limiting factor, and plankton levels have actually fallen over the past 50 years, not risen. As scientists discover more about Earth, vast numbers of positive and negative feedback loops are being discovered, that, together, maintain a metastable condition, sometimes within very broad range of environmental conditions. Environmental pressure, such as competition or change in temperature, can lead to adaptation/extinction of species over time.Reactive[edit source | editbeta]Example of use: "Reactive homeostasis is an immediate homeostasic response to a challenge such as predation."However, any homeostasis is impossible without reaction - because homeostasis is and must be a "feedback" phenomenon.The phrase "reactive homeostasis" is simply short for "reactive compensation reestablishing homeostasis", that is to say, "reestablishing a point of homeostasis." - it should not be confused with a separate kind of homeostasis or a distinct phenomenon from homeostasis; it is simply the compensation (or compensatory) phase of homeostasis.Other fields[edit source | editbeta]The term has come to be used in other fields, for example:Risk[edit source | editbeta]Main article: Risk homeostasisAn actuary may refer to risk homeostasis, where (for example) people that have anti-lock brakes have no better safety record than those without anti-lock brakes, because the former unconsciously compensate for the safer vehicle via less-safe driving habits. Previous to the innovation of anti-lock brakes, certain maneuvers involved minor skids, evoking fear and avoidance: now the anti-lock system moves the boundary for such feedback, and behavior patterns expand into the no-longer punitive area. It has also been suggested[citation needed] that ecological crises are an instance of risk homeostasis in which a particular behavior continues until proven dangerous or dramatic consequences actually occur.Stress[edit source | editbeta]Sociologists and psychologists may refer to stress homeostasis, the tendency of a population or an individual to stay at a certain level of stress, often generating artificial stresses if the "natural" level of stress is not enough.[citation needed]Jean-François Lyotard, a postmodern theorist, has applied this term to societal 'power centers' that he describes as being 'governed by a principle of homeostasis,' for example, the scientific hierarchy, which will sometimes ignore a radical new discovery for years because it destabilises previously accepted norms. (See The Postmodern Condition: A Report on Knowledge by Jean-François Lyotard)Psychological[edit source | editbeta]Author George Leonard discusses in his book Mastery how homeostasis affects our behavior and who we are. He states that homeostasis will prevent our body from making drastic changes and maintain stability in our lives even if it is detrimental to us.[12] Examples include when an obese person starts exercising, homeostasis in the body resists the activity to maintain stability.[13]Another example Leonard uses is an unstable family where the father has been a raging alcoholic and suddenly stops and the son starts up a drug habit to maintain stability in the family. Homeostasis is the main factor that stops people changing their habits because our bodies view change as dangerous unless it is very slow. Leonard discusses this dilemma as the media today only encourages fast change and quick results. The opening of his book aptly describes his despair with the current state of the world and how it is at war with homeostasis. "The trouble is that we have few, if any, maps to guide us on the journey or even to show us how to find the path. The modern world, in fact, can be viewed as a prodigious conspiracy against mastery. We're continually bombarded with the promises of immediate gratification, instant success, and fast, temporary relief, all of which lead in exactly the wrong direction." Urine formation begins with the process of filtration, which goes on continually in the renal corpuscles (Figure 3). As blood courses through the glomeruli, much of its fluid, containing both useful chemicals and dissolved waste materials, soaks out of the blood through the membranes (by osmosis and diffusion) where it is filtered and then flows into the Bowman's capsule. This process is called glomerular filtration. The water, waste products, salt, glucose, and other chemicals that have been filtered out of the blood are known collectively as glomerular filtrate. The glomerular filtrate consists primarily of water, excess salts (primarily Na+ and K+), glucose, and a waste product of the body called urea. Urea is formed in the body to eliminate the very toxic ammonia products that are formed in the liver from amino acids. Since humans cannot excrete ammonia, it is converted to the less dangerous urea and then filtered out of the blood. Urea is the most abundant of the waste products that must be excreted by the kidneys. The total rate of glomerular filtration (glomerular filtration rate or GFR) for the whole body (i.e., for all of the nephrons in both kidneys) is normally about 125 ml per minute. That is, about 125 ml of water and dissolved substances are filtered out of the blood per minute. The following calculations may help you visualize how enormous this volume is. The GFR per hour is:125 ml/min X 60min/hr= 7500 ml/hr.The GFR per day is:7500 ml/hr X 24 hr/day = 180,000 ml/day or 180 liters/day.Now, see if you can calculate how many gallons of water we are talking about. Here are some conversion factors for you to consider: 1 quart = 960 ml, 1 liter = 1000 ml, 4 quarts. = 1 gallon. Remember to cancel units and you will have no problem.Now, what we have just calculated is the amount of water that is removed from the blood each day - about 180 liters per day. (Actually it also includes other chemicals, but the vast majority of this glomerular filtrate is water.) Imagine the size of a 2-liter bottle of soda pop. About 90 of those bottles equals 180 liters! Obviously no one ever excretes anywhere near 180 liters of urine per day! Why? Because almost all of the estimated 43 gallons of water (which is about the same as 180 liters - did you get the right answer?) that leaves the blood by glomerular filtration, the first process in urine formation, returns to the blood by the second process - reabsorption.ReabsorptionReabsorption, by definition, is the movement of substances out of the renal tubules back into the blood capillaries located around the tubules (called the peritubular copillaries). Substances reabsorbed are water, glucose and other nutrients, and sodium (Na+) and other ions. Reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules (Figure 3). Let's discuss for a moment the three main substances that are reabsorbed back into the bloodstream.Large amounts of water - more than 178 liters per day - are reabsorbed back into the bloodstream from the proximal tubules because the physical forces acting on the water in these tubules actually push most of the water back into the blood capillaries. In other words, about 99% of the 180 liters of water that leave the blood each day by glomerular filtration returns to the blood from the proximal tubule through the process ofpassive reabsorption.The nutrient glucose (blood sugar) is entirely reabsorbed back into the blood from the proximal tubules. In fact, it is actively transported out of the tubules and into the peritubular capillary blood. None of this valuable nutrient is wasted by being lost in the urine. However, even when the kidneys are operating at peak efficiency, the nephrons can reabsorb only so much sugar and water. Their limitations are dramatically illustrated in cases of diabetes mellitus, a disease which causes the amount of sugar in the blood to rise far above normal. As already mentioned, in ordinary cases all the glucose that seeps out through the glomeruli into the tubules is reabsorbed into the blood. But if too much is present, the tubules reach the limit of their ability to pass the sugar back into the bloodstream, and the tubules retain some of it. It is then carried along in the urine, often providing a doctor with her first clue that a patient has diabetes mellitus. The value of urine as a diagnostic aid has been known to the world of medicine since as far back as the time of Hippocrates. Since then, examination of the urine has become a regular procedure for physicians as well as scientists.Sodium ions (Na+) and other ions are only partially reabsorbed from the renal tubules back into the blood. For the most part, however, sodium ions are actively transported back into blood from the tubular fluid. The amount of sodium reabsorbed varies from time to time; it depends largely on how much salt we take in from the foods that we eat. (As stated earlier, sodium is a major component of table salt, known chemically as sodium chloride.) As a person increases the amount of salt taken into the body, that person's kidneys decrease the amount of sodium reabsorption back into the blood. That is, more sodium is retained in the tubules. Therefore, the amount of salt excreted in the urine increases. The process works the other way as well. The less the salt intake, the greater the amount of sodium reabsorbed back into the blood, and the amount of salt excreted in the urine decreases.
 * FORMATION OF URINE
 * FLITRATION