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Gong Chen (neuroscientist)

Dr. Gong Chen is a neuroscientist working on brain and spinal cord repair to find a cure for the treatment of neurological disorders such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS, spinal cord injury, traumatic brain injury, brain cancer, etc.

Dr. Gong Chen and his team developed a NeuroD1-based in vivo glia-to-neuron conversion technology for brain and spinal cord repair. They demonstrated that overexpression of a single neural transcription factor NeuroD1 in reactive astrocytes after injury or disease can directly convert reactive astrocytes into functional neurons in the injury sites in situ.

Dr. Gong Chen and his team further developed a small molecule approach to directly convert cultured human astrocytes into functional neurons using chemically synthesized compounds.

Dr. Gong Chen and colleague wrote a perspective review article on the potential of in vivo cell conversion in brain and spinal cord repair.