User:GarrettAbernathy/sandbox

Causes "VLCADD (very long-chain-acyl-dehydrogenase disease) is exclusively linked to genetic mutations in DNA. A genomic change of the gene that codes for the very long-chain-acyl-CoA-dehydrogenase (VLCAD) results in a deficiency or malfunction of the produced VLCAD enzyme . This mutation is located on chromosome 17 and can be altered via a variety of pathways . These can range from frameshift mutations, deletion mutations, insertion mutations, and missense mutations. All of which cause the enzyme to function differently in the mitochondria or in some cases not at all . Due to this mutation, effective levels of very long-chain-acyl-CoA-dehydrogenase are low or absent in the body, giving rise to the array of symptoms listed above."Diagnosis Addition"Further evaluation of symptom combinations according to age group can aid in a positive diagnosis of VLCADD. Since symptoms vary depending on age and onset of the patient, consultation with a metabolic specialist should be considered. Diagnosis is further confirmed through genetic analysis of the VLCAD gene."Inheritance "VLCAD deficiency is characterized as a genetic inherited disorder. The mutations that occur within the gene itself are recessive, meaning that an individual has to acquire both recessive mutated genes in order for the disease to manifest. There are a few forms of the disease that can be manifested in infancy, adolescence, and adulthood. However, it is still unknown at to what causes the disease to manifest itself in the different life stages."