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Mary Frances Isom (February 27, 1865 in Nashville, Tennessee - April 15, 1920 in Portland, Oregon) was a librarian, and one of the founders of the Oregon Library Association, the Pacific Northwest Library Association and the Oregon State Library Commission. She was instrumental in the formerly private Portland Library Association being opened to the public as what is now the Central Library in Portland.

Biography
Mary Isom was born in Nashville, Tennessee in 1865 to Dr. John Franklin Isom and Frances A. Isom. Her family was originally from Cleveland, and returned there after the Civil War. She went to Wellesley for one year, but her college was interrupted at the end of that year so she could return to Cleveland to care for her father. When her father died in 1899, she enrolled at the library program at Pratt Institute and received her degree there two years later.

Shortly after she graduated, she was hired as a cataloger at the Library Association of Portland. The association had just received a gift from the philanthropist John Wilson of his entire collection of over 8,000 books, but it came with the stipulation that the collection must be made freely available to the public. The association needed a cataloger to help make these books accessible while they were making the final decisions on how their currently private association would go public By 1902, Isom had taken over as the head librarian of the association and was overseeing its transformation to a tax-funded public institution for all of Portland, and one year later it had become the library for all of Multnomah County.

Isom was active within the American Library Association (ALA) as well, drawing it to hold its national conference in Portland in 1905.

She worked with Cornelia Marvin in order to create a state and community-supported library system in Oregon.