User:Ghashiram/sandbox

Surendra Madhukat Ghaskadbi (born 1956) is an Indian developmental biologist. He has been associated with MACS-Agharkar Research Institute, Pune. His main research interests are cell signaling during pattern formation, evolution of developmental mechanisms and stem cell biology. He has used a variety of model systems, such as, chick and frog embryos, sponges, hydra and human mesenchymal and embryonic stem cells in his work. Over the past two decades, he has reintroduced hydra as a model system for teaching and research in India. His research has been funded by DST, DBT, CSIR, DAE (BRNS) and Indo-Japan grants. Dr. Ghaskadbi has published his work in reputed peer-reviewed journals and has several national and international collaborations. He has delivered a large number of talks in national and international meetings and student camps, and contributes to post-graduate teaching in many institutions in and outside Pune. Dr. Ghaskadbi has been associated with several scientific organizations in India. He has been President of Indian Society of Developmental Biologists, Vice President of Indian Society of Cell Biology and is an Elected Fellow of National Academy of Sciences India and Maharashtra Academy of Sciences.

Selected bibliogrpahy

Galande, A.A., Saijo, M., Ghaskadbi, S.S., and Ghaskadbi, S. (2021) Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells. J. Biosci., 46: 48 DOI: 10.1007/s12038-021-00170-6

Barve, A., Galande, A., A., Ghaskadbi, S.S. and Ghaskadbi, S. (2021) DNA repair repertoire of the enigmatic hydra. Front. Genet., doi: 10.3389/fgene.2021.670695.

Krishnapati, L.S., Khade, S. Trimbake, D, Patwardhan, R, Siva Kumar, N. and Ghaskadbi, S. (2020) Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles. Dev. Dyn., DOI: 10.1002/dvdy.238.

Ghaskadbi, S. (2020) Hydra: A powerful biological model. Resonance, 25, 1197-1213. DOI: https://doi.org/10.1007/s12045-020-1039-2. Haval, G.A., Pekhale, K.D., Perween, N.A. Ghaskadbi, S.M., and Ghaskadbi, S.S. (2020) Excess hydrogen peroxide inhibits head and foot regeneration in hydra by affecting DNA repair and expression of essential genes. J. Biochem. Mol. Toxicol., doi.org/10.1002/jbt.22577 Ghaskadbi, S. (2020). Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways. Int. J. Dev. Biol., 64: 141-149. doi: 10.1387/ijdb.190243sg Ghaskadbi, S. and Nanjundiah, V. (2020). One of the most significant discoveries in developmental biology from an Indian laboratory – Iqbal A. Niazi and the role of retinoids in limb regeneration. Int. J. Dev. Biol., 64: 71-97. doi: 10.1387/ijdb.200103in Ghaskadbi, S. (2020) Leela Mulherkar and the teaching of developmental biology. Int. J. Dev. Biol., 64: 41-44. doi: 10.1387/ijdb.200147sg Niazi, I.A. and Ghaskadbi, S. (2020) A brief history of the Indian Society of Developmental Biologists (InSDB). Int. J. Dev. Biol., 64: 5-6. doi: 10.1387/ijdb.200146sg Ghaskadbi, S. and Nanjundiah, V. (2020) Developmental Biology in India (Preface). Int. J. Dev. Biol., 64: 1-4. doi: 10.1387/ijdb.200101vn Turwankar, A. and Ghaskadbi, S. (2019) VEGF and FGF signaling during head regeneration in hydra. Gene, 717: doi: 10.1016/j.gene.2019.144047. Galande, A.A., Perween, N., Saijo, M., Ghaskadbi, S.S. and Ghaskadbi, S. (2018) Analysis of the conserved NER helicases (XPB and XPD) and UV-induced DNA damage in hydra. Biochim. Biophys. Acta, 1862: 2031-2042. doi: 10.1016/j.bbagen.2018.06.017. Bhamidimarri, P.M., Krishnapati, L.S., Ghaskadbi, S., Nadimpalli, S.K. (2018) Mannose 6-phosphate-dependent lysosomal enzyme targeting in hydra: a biochemical, immunological and structural elucidation. FEBS Lett., 592: 1366-1377. Londhe, R., Krishnapati, L. S. and Ghaskadbi, S. (2017) Description and phylogenetic characterization of hydra from Naukuchiatal (Uttarakhand, India) and comparison with other Hydra strains. Curr. Sci., 113: 1739-1745. Pekhale, K., Haval, G., Perween, N., Antoniali, G., Tell, G., Ghaskadbi, S. and Ghaskadbi, S. (2017) DNA repair enzyme APE1 from evolutionarily ancient Hydra reveals redox activity exclusively found in mammalian APE1. DNA Repair, 59:44-56. Dixit, N.S., Shravage, B.V. and Ghaskadbi, S. (2017) Identification and characterization of the autophagy-related genes Atg12 and Atg5 in hydra. Int. J. Dev. Biol., 61: 389-395. Zeeshan, M., Murugadas, A., Ghaskadbi, S., Ramaswamy, B.R. and Akbarsha, M.A. (2017) Ecotoxicological assessment of cobalt using Hydra model: ROS, oxidative stress, DNA damage, cell cycle arrest, and apoptosis as mechanisms of toxicity. Env. Poll., 224: 54-69. Murugadas, A., Zeeshan, M., Thamaraiselvi, K., Ghaskadbi, S. and Akbarsha, M. A. (2016) Hydra as a model organism to decipher the toxic effects of copper oxide nanorod: Ecotoxicogenomics approach. Sci. Rep., 6:29663 | DOI: 10.1038/srep29663

Krishnapati, L.S., Londhe, R., Deoli, V., Barve, A., Ghaskadbi, S. and Ghaskadbi, S. (2016) UV radiation-induced ectopic foot formation in regenerating hydra is mediated by up-regulation of metalloproteinases and inactivation of Wnt pathway. Int. J. Dev. Biol., 60: 111-117.

Zeeshan, M., Murugadas, A., Ghaskadbi, S., Rajendran, R.B. and Akbarsha, M.A. (2016) ROS dependent copper toxicity in Hydra-biochemical and molecular study. Comp. Biochem. Physiol. C Toxicol Pharmacol., 185-186: 1-12.

Gaikwad, S., Chowdhury, S.P., Shouche, Y.S., Ghaskadbi, S. and Ghaskadbi, S. (2016) Laboratory maintained and wild populations of Hydra differ in their microbiota. Ann. Microbiol., 66: 931-935. Krishnapati, L.S. and Ghaskadbi, S. (2016) Insulin induces the expression of FGF2 but does not synergize with it during angiogenesis. Microvascular Res., 103:55-63.

Dasgupta, A., Sawant M.A., Lavhale, M.S., Krishnapati, L.S., Ghaskadbi, S., Sitaswad, S.L. (2015) AECHL-1, a novel triperpenoid, targets tumor neo-vasculature and impairs the endothelial cell cytoskeleton. Angiogenesis 18: 283-299.

Jain, B.P., Chauhan, P., Tanti, G.K., Singarapu, N., Ghaskadbi, S., Goswami, S.K. (2015) Tissue specific expression of SG2NA is regulated by differential splicing, RNA editing and differential polyadenylation. Gene 556:119-126.

Krishnapati, L. S.  and  Ghaskadbi, S. (2013) Identification and characterization of VEGF and FGF from Hydra Int. J. Dev. Biol. 57: 897-906.

Barve, A., Ghaskadbi, S. and Ghaskadbi, S. (2013) Structural and Sequence Similarities of Hydra Xeroderma Pigmentosum A Protein to Human Homolog Suggest Early Evolution and Conservation. BioMed Res. Int., Article ID 854745, 9 pages. doi:10.1155/2013/854745

Barve, A., Ghaskadbi, S. and Ghaskadbi, S. (2013) Conservation of the nucleotide excision repair pathway: Characterization of hydra xeroderma pigmentosum group F homolog. PLOS ONE, 8(4): e61062. doi:10.1371/journal.pone.0061062.