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In one study, serum bone alkaline phosphatase (B-ALP) was measured in children with normal levels of growth hormone (GH) and those with growth hormone deficiency while undergoing GH therapy. The study reveals that children with normal amounts of GH have the highest levels of serum bone alkaline phosphatase during infancy and puberty, periods of accelerated growth, and children with GH deficiency are shown to have a significant increase in serum B-ALP after three months to a year of GH therapy. In addition, GH treatment has shown to improve the speed of growth in height and increase in bone density. The increase in B-ALP levels throughout the length of the therapy as well as its activity in normal children, indicates a positive correlation between serum B-ALP levels with bone formation in humans.