User:Gloryrunner13/sandbox

References
 * 1) Summary (Function)
 * 2) Localized in dendrites and cell body (1)
 * 3) Mediator of apoptosis in hippocampal, cortical and granule neurons (1)
 * 4) Apoptosis function induced by increase in reactive oxygen species (ROS)
 * 5) Structure
 * 6) Functional Alpha Subunit (4), (8)
 * 7) All K+ channels have a pore of alpha-subunits; one to two copies of a conserved loop P-domain
 * 8) P-domain contains selectivity sequence allowing only K+ ions, and only those of a certain class (“functional diversity of families”)
 * 9) Associate with auxiliary cytoplasmic beta subunits
 * 10) 2 types: 6TM spanning regions, 2TM regions
 * 11) 6TM: conserved gene families: Kv, KCNQ, EAG-like, and Ca activated
 * 12) 2TM: inward rectifying
 * 13) Large number of phosphorylation sites (1)
 * 14) Regulation
 * 15) Expression is developmentally regulated (1)
 * 16) Poorly conducting in phosphorylated state (1)
 * 17) Blockers
 * 18) Selectivity
 * 19) Stromatoxin- voltage-clamp experiments; low selectivity (2)
 * 20) Hanatoxin- inhibits K+ voltage gated channel activation (2)
 * 21) Guangxitoxin-1E- high selectivity for Kv2 channels (2)
 * 22) Kinetics
 * 23) Repolarization
 * 24) N- and C-terminal regions are main factors in activation kinetics of this channel. (3) (5)
 * 25) Channelopathies/Mutations
 * 26) Epileptic Encephalopathy (6)
 * 27) Developmental Disabilities
 * 28) Deficiencies in: neurotransmitter regulation, heart rate, insulin production, hearing, etc.
 * 29) Physiological Roles in Diseases
 * 30) Neurodegenerative Diseases: Oxidative modulation of K2.1 channels contributes to altered excitability, progression of neurodegenerative diseases, and healthy aging. (7)
 * 31) Diabetes (Pancreatic Bcell Signaling) : K(+) efflux mediated by KV2.1 delayed rectifier K(+) channels acts as a brake for insulin secretion. (9) (10)
 * 32) Alzheimers: Injury-mediated increased K(+) efflux through Kv2.1 channels promotes neuronal apoptosis, contributing to widespread neuronal loss in neurodegenerative disorders such as Alzheimer's disease. (11)
 * 33) Pharmocology
 * 34) Anti-apoptotic strategy (1)
 * 35) CO can protect against an increase in KCNC1 current by regulating ROS and PKG
 * 36) Cancer cells and chronic viruses produce excess CO
 * 1) http://www.wjgnet.com/1949-8454/full/v5/i2/85.htm
 * 2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972724/
 * 3) https://www.ncbi.nlm.nih.gov/pubmed/14608450
 * 4) https://www.ncbi.nlm.nih.gov/pubmed/12451110
 * 5) https://www.ncbi.nlm.nih.gov/pubmed/18607586
 * 6) http://www.pcmicroscopycore.com/the-jordyn-project-kcbn1
 * 7) https://www.ncbi.nlm.nih.gov/pubmed/25333910
 * 8) https://www.ebi.ac.uk/interpro/entry/IPR005400
 * 9) https://www.ncbi.nlm.nih.gov/pubmed/25052376
 * 10) https://www.ncbi.nlm.nih.gov/pubmed/20711225
 * 11) https://www.ncbi.nlm.nih.gov/pubmed/24323720