User:Glueck CJ/sandbox

Osteonecrosis (bone death) can be caused by inherited and/or acquired coagulation disorders (thrombophilia, hypofibrinolysis). It is thought that blood clots (thrombi) occlude the osseous vein (particularly in the knee), leading to increased intra-osseous pressure, reduction-stopping of oxygenated arterial blood flow, and subsequent bone death. If the coagulation disorders can be diagnosed before collapse of the hip or knee, and if thrombophilia-hypofibrinolysis are present, then anticoagulation with Eliquis or Xarelto may be successful in allowing oxygenated blood to return to the joint, relieving pain, and preventing joint collapse. Further information can be obtained from pubmed.gov (Glueck CJ, osteonecrosis).