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 * Kevin Richardson-Craig Torrance (season 1-6). Head of Medicine at Scholer Hospital and brother of Julian Torrance. Torrance begins dating fellow doctor Daria Gibson in season 2 until she leaves him in the beginning of season 6. Torrance leaves his job and the hospital at the end of season 6 in a desperate attempt to find Daria and reconcile, though it is believed by many that he actually went back to his home and committed suicide. Torrance returned for a few episodes in season 12 (this time played by Joe Davis) in the form of visions that his brother Julian was seeing during a particular hard time in his life.
 * Billy Bishop-Julian Torrance. Head of Surgical Operations (season 1-6), later Head of Medicine (season 7-present) and brother of Craig Torrance.
 * Brett Gallagher-Danny Phillips (season 1-2, 4-5, 8-9, 12-present). Neurologist and one of Craig Torrance’s (and later Julian Torrance’s) fellows.
 * Scott Wilson-Grant Cook (season 1-2, 3-5, 8, 10-11). Surgeon, Cardiologist, and one of Craig Torrance’s (and later Julian Torrance’s) fellows.
 * Laurie Wilson-Liz Jennings (season 1, 5-9). Diagnostician, and one of Craig Torrance’s (and later Julian Torrance’s) fellows.
 * James Lloyd-Jeremy Walsh (season 2-3, 6-8, 10-11). Neurologist and one of Craig Torrance’s (and later Julian Torrance’s) fellows.
 * Chris Fisher-Kyle Shepherd (season 2-3, 6-7, 9). Surgeon, Cardiologist, and one of Craig Torrance’s (and later Julian Torrance’s) fellows.
 * Gillian Archer-Kristine Jones (season 2-4). Diagnostician, and one of Craig Torrance’s fellows.
 * Margaret Schmidt-Liv Christiansen (season 10-11). Diagnostician and one of Julian Torrance’s fellows.
 * Allison Polk-Whitney Fisher (season 12-15). Diagnostician, Surgeon, and one of Julian Torrance’s fellows.
 * Jason Elliot-Derek Stewart (season 12-15). Surgeon, Cardiologist, and one of Julian Torrance’s fellows.
 * Julie Harris-Brianne Lacey (season 16-present). Surgeon, Cardiologist, and one of Julian Torrance’s fellows.
 * Evan Baker-Jake Davidson (season 16-present). Diagnostician, and one of Julian Torrance’s fellows.

Recurring

 * Allison Baker-Ellen Torrance. Cancer specialist and Julian Torrance’s wife.
 * Matt Sparks-Jordan Lewis. Surgeon and Julian Torrance’s best friend.
 * John Carter-Austin Kelly (season 1-8, 13-present). Hospital Receptionist (season 1-8), E.R. Trainee (season 13-present) and Craig Torrance’s best friend. He was said to have gone back to college during seasons 9-12 to become a doctor.
 * June Ivey-Daria Gibson (season 2-5). Endocrinologist and Craig Torrance’s girlfriend. Gibson leaves Torrance at the beginning of season 6, devastating him.
 * Don Barnes-Gavin Arnold (season 1-5, 8-12). Dean of Medicine.
 * Sean Clark-Jake Travis (season 6-7). Dean of Medicine.
 * Clair Gaines-Faith Walsh. Dean of Medicine (season 13-present) and Jeremy Walsh’s sister.

Guest

 * Lorraine Stewart-Valerie Torrance. Craig and Julian’s mother.
 * Mark Guilbert-Peter Torrance. Craig and Julian’s father.
 * Laura Anderson-Julie Travis (season 6-7). Jake Travis’ wife.
 * Joe Davis-Craig Torrance (season 12, episodes 5, 9, 12, and 18). He appeared in the form of visions seen by his brother during a particularly hard time in his life.
 * Shawn Blake-Josh Sepatorre (season 13, 15). Faith Walsh’s husband.