User:GreatDane15/sandbox

Week of 9/21/2020-9/26/2020

Comparing Rotavirus article and Canine Parvovirus article

The Canine Parvovirus article does not have a large focus on the structure of the parvovirus molecule, in comparison to the Rotavirus article that explains the structure and how the virus works on a molecular and genetic level. The Canine Parvovirus article only mentions the relation of the pathogen to other viruses instead of the molecular and genetic workings of the virus. The article then continues to focus on treatment and diagnosis, history, and describes the various forms of parvovirus.

Due to the parvovirus article focusing more on treatment and diagnosis, and descriptions of the various forms, there are not many sources. It seems that it almost comes from a perspective of experience rather than scientific documentation. The Rotavirus article has sources for almost every statement, especially for those that focus on the structure and function of the virus. also because the Canine Parvovirus article seems to be written from experience more, there is some lack of describing the symptoms or other complications that occur that are mentioned within the article.

Both have the history of the virus and its discovery located in the article.

Canine Parvovirus article Additions

Overall: I would like to find more sources for the whole article. CPV and CPV2 are used interchangeably in the article, this should not be done because they are two different strains of parvovirus.

Signs: I want to add a link to diarrhea in the second sentence in this paragraph because others may not know what this is. At the end of this section it mentions that the white blood cell count can decrease but there is no explanations of how the white blood cells fight off the infection. I think it would be good to add this information in.

Diagnosis: There is not an explanation of PCR, so I would like to add an explanation of what that is within the article so as to give more background information. There is a mention of the various forms of parvovirus (cardiac, intestinal, fetus) at the end of this section so the explanations and descriptions of these forms should be moved to after this section instead of after the history.

Treatment: there is no explanation of what ileus is within the article and there is not a link explaining what this is, so I would like to add this in. There is a mention of human plasma being used as a treatment but there is no source for this information. I would like to find a source for this or remove it if it is not credible. Much of this section is not cited and seems to be written from the perspective of someone that has experienced a pet with parvovirus or something similar. This seems not credible to me and should be revised.

Sources

https://www.avma.org/resources-tools/pet-owners/petcare/feline-panleukopenia

Stuetzer B, Hartmann K. Feline parvovirus infection and associated diseases. Vet J. 2014;201(2):150-155. doi:10.1016/j.tvjl.2014.05.027

Week of 9/27/2020-10/3/2020

Intro Paragraph

Change: "Vaccines can prevent this infection, but mortality can reach 91% in untreated cases." --> Vaccines can prevent a CPV infection, but mortality can increase if the virus is left untreated. Adult canines may have a mortality rate of 10% and puppies may have a higher mortality rate of 91% if they become infected with CPV.

Change: "Canine parvovirus may infect other mammals including foxes, wolves, cats, and skunks." --> Canine parvovirus and its variants may infect other mammals including foxes, wolves, cats, and skunks.

Remove: "Felines are susceptible to panleukopenia, a different strain of parvovirus." -- This sentence sounds awkward at the end of the paragraph.

Signs

Add: Citations for the paragraph or a note that all of the information in the paragraph can be found in source 3.

Add: CPV2 can cause HGE, or acute hemorrhagic enteritis in infected individuals. Acute Hemorrhagic enteritis has a variety of causes, none of which have been identified as a sole cause of HGE and can occur suddenly, exhibiting bloody diarrhea and vomiting. CPV2 can also cause myocarditis in infected individuals, which is where the tissues in the heart become irritated and inflamed, this can lead to irregular hearth rhythms and respiratory issues such as coughing or shallow breathing.

Remove: "Younger animals have worse survival rates." Survival rate has other factors besides age of the animals.

Week of 10/4/2020-10/10/2020

Diagnosis

Change: "Clinically, the intestinal form of the infection can sometimes be confused with coronavirus or other forms of enteritis." --> CPV2 may be confused with canine coronavirus (CCoV) which can cause diarrhea or respiratory issues, but is not the same strain as SARS-CoV-2. Enteritis can present similar symptoms as CPV2.

Treatment

Add: Source for Treatment section: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053044/, https://link.springer.com/article/10.1007/s13337-010-0007-y, this section of the article is well written and well supported, but needs more citations.

Remove: "Additionally, fresh frozen plasma and human albumin transfusions can help replace the extreme protein losses seen in severe cases and help assure adequate tissue healing. However, this is controversial with the availability of safer colloids such as Hetastarch, as it will also increase the colloid osmotic pressure without the ill effect of predisposing that canine patient to future transfusion reaction." --> I was not able to find any scholarly articles that supported or opposed the use of human albumin as a treatment for animals diagnosed with CPV2. I was also unable to find any articles that explained this as a treatment option.

Treatments in Development

Unclear: I was unable to find other articles discussing this form of treatment.

Unconventional Treatments

Unclear: I am not sure if a suggestion of in home treatment should be here, but it is properly cited and explained.

Add: Include the sources above under the Treatment section, as well as others found within the article to see what treatment should entail.

History

Week of 10/11/2020-10/17/2020

Adding a lead as suggested by peer reviews

Lead

Canine Parvovirus, or CPV-2 is a potentially fatal virus that may have evolved from feline panleukopenia and can infect animals such as canines, felines, foxes, wolves, and skunks. This virus mainly infects canines and can be treated symptomatically. It enters the body though contact with feces of other infected animals and can only be treated symptomatically if contracted. There is a vaccine that can be given as boosters to puppies younger than one year, and a yearly vaccine that is given to adults.