User:HBOerasmus/sandbox

Neurological:
Cerebrovascular diseases occur due to insufficient oxygen supply to central neural tissue. When that happens, the primary damage of brain tissue cannot recover and it is a leading cause of death. Adequate therapy with oxygen supply can minimize secondary tissue impairment and can restore the neuronal function. Therapy with HBO reopens occluding vessels and is essential for the survival of neural tissue. . In addition, HBOT regenerates axons to reinstate the functioning of nerves. The clinical experience and results so far published has promoted the use of HBO therapy in patients suffering from cerebrovascular injury and focal cerebrovascular injuries,. However, the power of clinical research is limited because of the shortage of randomized controlled trials.

Diabetes:
When suffering from Type 1 Diabetes, HBOT might be a useful therapy. The health of diabetic rats improved drastically after Hyperbaric oxygen therapy because of the higher blood glucose levels and increased muscle oxygenation in the region of the feet. These effects potentially have a beneficial influence on future presentation of a diabetic ulcer. In addition, there also are signs that HBOT has an immunogenic advantage of for treating Type 1 Diabetes. The destructive effect on pancreatic beta cells can be inhibited by increasing the resting T-cells and diminish dendritic cells. However, this therapy might only be helpful in a pre-emptive timeframe. No evidence has been found on beneficial oxygen therapy response, when already in a prediabetic stage. Therefore, HBOT can induce both positive and negative effects, depending on the phase of the disease.

Radiation Wounds:
There has been positive results for neoadjuvant HBOT in combination with radiotherapy. After this therapy, tumors showed an apparent growth delay. On the other hand, HBOT inhibits both the growth and differentiation of osteoblasts. These effects could have a negative effect on necrotic tissue proliferation and bone generation, which would not help in therapy of radiation wounds. Many studies indicate a positive share of HBOT after radiation injury. However, no significant evidence was found on HBOT having either a positive or negative effect on radiation wounds. This might be explained due to the lack of experimental and clinical studies.

Chronic Ulcers
A review in 2012, focusing on diabetic foot ulcers, concluded that HBOT is an advantageous complement regarding major amputation. Also, significant reduction of wound size was found after treatment with HBOT compared with other treatments. For venous, arterial and pressure ulcers, no evidence was apparent that HBOT provides an improvement on standard treatment.

Neurological and Radiation
There are signs that HBOT might improve outcome in late radiaton tissue injury affecting bone and soft tissues of the head and neck. In general patients with radiation injuries in the head, neck or bowel showed an improvement in quality of life after HBO therapy. On the other hand, no such effect was found in neurological tissues. The use of HBOT may be justified to selected patients and tissues, but further research is required to establish the best patient selection and timing of any HBO therapy.