User:HRShami/Rajiv Jalan

Rajiv Jalan is an American clinician, researcher and academic. He is a Professor of Hepatology at the Institute for Liver and Digestive Health, University College London Medical School and the Head of Liver Failure Group. He is also an Honorary Consultant at Royal Free Hospital and University College London Hospitals. He is the former Editor in Chief of Liver International (2012 to 2014) and of the Journal of Hepatology (2015 to 2019).

Jalan's work is focused on translational research in the area of liver failure. His research has led to publications of about 370 original papers, editorials and reviews.

Early life and education
After graduating from La Martiniere in Calcutta, Jalan completed his MD in Heptology at Edinburgh University in 2000. He then joined Maastricht University, completing his Ph.D. in 2005.

Career
Jalan joined UCL as a Senior Lecturer and Honorary Consultant in 2000 and was awarded a personal chair in 2009.

Jalan is closely involved with developing guidelines, setting standards of care leading up to being elected Secretary of the British Association for the Study of Liver diseases in 2009. He liaises closely with the Department of Health in defining structure and organization of liver disease services for the UK and with the Department of Transport in developing statutes for driving in liver disease patients.

Jalan has provided leadership in ACLF research resulting in the formation of the European Chronic Liver Failure Study Group in 2006 and then the EASL CLIF Consortium in 2009. The EASL CLIF Consortium then became absorbed into the European Foundation for Chronic Liver failure that is independently funded and later developed a translational research arm. Jalan served as the elected President of the International Society of Hepatic Encephalopathy and Nitrogen metabolism from 2012 to 2014. From 2012 to 2014, he worked as the Editor in Chief of Liver International and from 2015 to 2019, he worked as the Editor in Chief of Journal of Hepatology.

Jalan is the co-founder of three companies, Yaqrit, Cyberliver and Ammun. These companies further develop some of the inventions of the Liver Failure Group.

Research and work
Jalan's research is focused on liver failure. He began research of variceal bleeding in 1991. His research in this area continued until 1997 and led to the establishment of TIPSS for tje treatment of variceal bleeding. Starting in 1999, some of his research has dealt with the treatment of Acute Liver Failure patients with uncontrolled intracranial hypertension using hypothermia. His research from 2001 to 2005 led to the development of albumin dialysis as treatment for pruritus and acute or chronic liver failure.

Jalan's most significant contribution is the discovery that systemic inflammation played a crucial role in the progression of liver injury and cirrhosis culminating in liver failure leading up to current hypotheses and the observation that acute-on-chronic liver failure (ACLF) was a distinct clinical syndrome with defined clinical, prognostic and pathophysiological characteristics.

Jalan has developed a clinical practice and laboratory with many novel therapies and and established extensive collaborations with key investigators, Foundations and Industry around the world to study the pathophysiological basis of ACLF.

Publications

 * Angeli, P., Ginès, P., Wong, F., Bernardi, M., Boyer, T. D., Gerbes, A., … Garcia-Tsao, G. (2015). Diagnosis and management of acute kidney injury in patients with cirrhosis: Revised consensus recommendations of the International Club of Ascites. Journal of Hepatology, 62(4), 968–974.
 * Bañares, R., Nevens, F., Larsen, F. S., Jalan, R., Albillos, A., Dollinger, M., … Arroyo, V. (2013). Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial. Hepatology, 57(3), 1153–1162.
 * Jalan, R., Damink, S. W., Deutz, N. E., Lee, A., & Hayes, P. C. (1999). Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. The Lancet, 354(9185), 1164–1168.
 * Jalan, R., Saliba, F., Pavesi, M., Amoros, A., Moreau, R., Ginès, P., … Arroyo, V. (2014). Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. Journal of Hepatology, 61(5), 1038–1047.
 * Maartje A. J. Van Den Broek, Damink, S. W. M. O., Dejong, C. H. C., Lang, H., Malagó, M., Jalan, R., & Saner, F. H. (2008). Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liver International, 28(6), 767–780.
 * Moreau, R., Jalan, R., Gines, P., Pavesi, M., Angeli, P., Cordoba, J., … Arroyo, V. (2013). Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis. Gastroenterology, 144(7).
 * Sarin, S. K., Kumar, A., Almeida, J. A., Chawla, Y. K., Fan, S. T., Garg, H., … Yuen, M.-F. (2008). Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatology International, 3(1), 269–282.
 * Sen, S., Williams, R., Jalan, R., Sen, S., Williams, R., & Jalan, R. (2002). The pathophysiological basis of acute-on-chronic liver failure. Liver International, 22(s2), 5–13.
 * Shawcross, D. L., Davies, N. A., Williams, R., & Jalan, R. (2004). Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. Journal of Hepatology, 40(2), 247–254.
 * Wong, F., Nadim, M. K., Kellum, J. A., Salerno, F., Bellomo, R., Gerbes, A., … Arroyo, V. (2011). Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut, 60(5), 702–709.