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Premia Spine, Ltd. (Hebrew: פרמיה ספיין בע"מ) is a medical device company developing and manufacturing posterior orthoplastic implants. The company offers alternative solutions to static lumbar spinal fusion surgery . Its flagship product, TOPS™, is a clinically superior solution for spinal stenosis or spondylolisthesis (“slipped disc”), the two most prevalent degenerative spine diseases afflicting patients over the age of 40 years. Founded in 2011, Premia Spine employs XX medical device specialists in Nethanya, Israel and its products are available in Germany, Austria, Britain, Belgium and Turkey, as well as in Israel.

Corporate History
The TOPS™ System originated at the Israeli orthopedic device company Impliant, which Ron Sacher joined as CEO in 2001. The company then decided to transition from classic orthopedics to spinal implants. After ascertaining that the most frequent spinal disease in people over 40 years old was spinal stenosis, the company chose to focus on the need for better clinical outcomes than fusion surgery. From 2004 to 2010, Impliant invested $50 million in the TOPS™ System, bringing the motion preserving alterative to fusion from the concept stage through lab testing to clinical validation. Though Ron Sacher left Impliant in 2007 to co-found another medical device company he later sold to Boston Scientific, in 2011 he acquired the TOPS™ System’s 20 worldwide patents, and restarted the company as Premia Spine.

Market
The worldwide addressable market for the TOPS™ System is over $1 billion. As much as 70 percent of the population experiences debilitating back pain due to a spinal condition at some time in their lives. Spinal stenosis of the lower back (known as lumbar spinal stenosis) is among the most common of these spinal disorders. Premia Spines's TOPS™ System provides better clinical outcomes following spinal decompression than spinal fusion back surgery for patients with moderate to severe symptoms of spinal stenosis.

Products
Premia Spine flagship product, TOPS™, is a pedicle screw based device implanted posteriorly to reconstruct the motion segment. It is a unitary device composed of two titanium end plates with an interlocking polycarbonate urethane articulating core. The device mimics the natural kinematics of the spine for controlled motion and sagittal stabilization. The TOPS™ System is designed to resist excessive motion in flexion, extension, lateral bending, axial rotation and sagittal translation. No other device thoroughly covers all directions and ranges of motion.

The TOPS™ System is approved for sale in Europe under a CE mark. In the United States, the TOPS™ System is an Investigational Device limited by Federal (USA) law exclusively for use by or on the order of a physician under Clinical Investigation.