User:Hammernmill/sandbox

I want to add the following information to 'segmented filamentous bacteria but do not seem to be doing one or more things right.

Research on maternal immune activation in mice has demonstrated typical social and repetitive behaviors in offspring when segmented filamentous bacteria were absent from the guts of the mothers. However, if the guts of female mice contained segmented filamentous bacteria, the offspring showed atypical social and repetitive behaviors. These atypical behaviors were linked to changes in the dysgranular zone of the primary somatosensory cortex (S1DZ). The research further found that optogenetically engineered mice could have these abnormalities activated or inhibited in response to various wavelengths of light. A separate element of this research determined the S1DZ neurons project into a specific region of the mouse cortex, the temporal association area (TeA), in addition to the striatum. It is suggested that even if these aspects of mouse physiology are not linkable to autism in humans, it still suggests the complexity of the interactions between gut bacteria, the maternal immune system, and development of fetal brain structures and the subsequent consequences in terms of offspring behaviors.

Hammernmill (talk) 22:22, 4 October 2017 (UTC)