User:Haned6011/RNA binding protein proposal

Wikipedia Project Proposal: RNA-binding proteins

Brianna Lacarubba Eun Young (Anna) Han So hee Kim

Current information on Wikipedia page: Only general definition of RNA-binding protein is present without much detail on its functions, structure and types.

Outline

1) General overview of RNA-binding protein

2) History of RNA-binding protein

3) General structure and an interaction with RNA

-Modular design of RNA-binding proteins

4) RNA-binding activity and recognition (specificity) of RNA sequences

5) Diversity of RNA-binding proteins

-mRNA binding proteins

-snRNA binding proteins

-micro-RNA binding proteins


 * Specific examples will be included

6) Post-transcriptional control

- Biogenesis

- Stability

- Function

- Transport

- Cellular localization


 * Specific examples will be included

7) RNA-binding proteins’ function during germ line and embryonic development

8) Recent findings

-Role of RNA-binding protein Sam68 on dendrites

-Effects of RNA-binding protein Slr1 on Candida albicans filamentation and virulence

-An RNA-binding protein associated with Src in mitosis

Sources:

http://www.ncbi.nlm.nih.gov/pubmed/18342629

http://www.wormbook.org/chapters/www_RNAbindingproteins/RNAbindingproteins.html

http://www.ncbi.nlm.nih.gov/pubmed/23382180

http://www.nature.com/nature/journal/v368/n6474/abs/368867a0.html

http://www.ncbi.nlm.nih.gov/pubmed/23381995

https://docs.google.com/viewer?a=v&q=cache:gpIFH2udx6EJ:www.oup.com/uk/orc/bin/9780199288373/ch04.pdf+Chapter+04:+The+RNA-binding+proteins+-+Oxford+University+Press&hl=ko&gl=kr&pid=bl&srcid=ADGEESioAC6PHh1UMQJt_dDftmZ3ruodNaxXfQ3Dq7wSCd94ntf9xfFO1sAgwY5EZZQz4VAlnhzW6gVLmSQ_ix6D_fO_1bA1xArSjWlMIaZyXX-o4I0eA7Kz-bzb1EJ6a20HXDNm8BM2&sig=AHIEtbRMHRIzrvkOPm7TPjaG7_2dZ0mnOA

http://www.nature.com/nrm/journal/v3/n3/full/nrm760.html

http://www.nature.com/nrm/journal/v8/n3/full/nrm2124.html#top

http://www.nature.com/nrm/journal/v8/n6/full/nrm2178.html

http://rbpdb.ccbr.utoronto.ca/

Work-load distribution:

So hee Kim: Section 1,2,3,4

Brianna Lacarubba: Section 5,6

Eun Young (Anna) Han: Section 7,8


 * Subject to change