User:Hannah Geer/sandbox

Article Evaluation (Cell Adhesion)

Everything in this article is relevant to cell adhesion, and it stays focused on that topic throughout the entire paper.

All the information is up to date, and to my knowledge there is no missing information.

To improve the paper, more explanation of the individual junctions would help.

The article is neutral.

All the viewpoint are represented equally.

The citations I checked work, and they all are relevant to cell adhesion.

Facts are referenced properly.

The conversation in the talk page is different people giving ideas of how to improve the article.

The article is part of the WikiProject Molecular and Cell Biology.

This article goes more in depth than we did in class.

Article Sources
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Source two.

Source three. The second dosage compensation that occurs in mammals are the balancing of X’s and autosomes. This regulation occurs by the upregulation of Xa, which is the active X. The upregulation of the active X shows increases in the activation of transcription and elongation. The X chromosome, compared to an autosomal gene, contains more silent genes which influences measuring the amount of influence active genes have. RNA-seq data was preformed and the autosomal and X linked gene outpus were significantly different. This agrees with the fact that X dosage compensation is in respect to autosomes(1). The loss of an X chromosome leads to an aneuploidy effect which disrupts the entire cell in Drosophila. This effect leads to the disruption of MSL (male specific lethal) from binding onto its target site. To overcome this, the X chromosome is first hyperactivated. Then, the hyperactivated X chromosome facilitates the inversion of the aneuploidy effect to create a gene expression equality between males and females. An aneuploidy effect is when the number of chromosomes is increased or decreased from normal. (2) Ohno’s hypothesis, which states the male X chromosome is hyperactivated and one of the female X chromosomes is deactivated, was found to be inaccurate. Natural selection occurs efficiently in Drosophila so the genes that are dosage-sensitive are increased. The dosage-sensitive genes vary from species to species. (3)