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Bone Morphogenic Proteins (BMPs) are proteins that are made of acidic polypeptides. BMPs promotes the regeneration of bone tissue and cartilage. Bone Morphogenic Protein-2 (BMP-2) works along with Vascular Endothelial Growth Factors to (VEGF-165) in a complex cascade of signaling pathways to induce the regeneration of bone tissue. VEGFs works as angiogenic factors, where as BMPs work as osteogenic factors. The dual combination of these factors can induce a system of vascularization in bones, which can help in bone repair and regeneration.