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The Battelle National Biodefense Institute (BNBI) is an American non-profit organization. BNBI houses and operates the National Biodefense Analysis and Countermeasures Center for the U.S. Department of Homeland Security.

The institute itself also conducts research and development and manufactures several products.

Battelle runs a 160,000-square-foot facility. The campus houses a "Biosafety Level-4 high-security research laboratory, where scientists handle some of the world's most dangerous agents" such as anthrax and Ebola. Scientists also do research on pathogens that don't yet have a treatment or vaccine.