User:Hayleysmitty18/Liothyronine

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It can be taken by mouth or by injection into a vein. The dose of liothyronine for treatment of hypothyroidism would be concentrated at a lower amount than what it would be for levothyroxine due it being a higher concentrated synthetic medication.[1]

Liothyronine is a generally less preferred option to levothyroxine (T4) for people with hypothyroidism [1]. It may be used when there is an impaired conversion of T4 to T3 in peripheral tissues [1]. This is due to the fact that T4 is a prohormone and must be converted to T3 in the peripheral tissues by the human body naturally for biological functions.[5] A b out 25 ug of liothyronine is equivalent to 100 ug of levothyroxine [2]. Liothyronine may also be used for myxedema coma because of its quicker onset of action when compared to levothyroxine. A combination of liothyronine and levothyroxine has been a successful form of treatment for a myxedema coma, where liothyronine is used at a lower dosage than levothyroxine and was then discontinued.[8] Use for the treatment of obesity is not recommended.

Citations:

[5] Schroeder AC, Privalsky ML. Thyroid hormones, t3 and t4, in the brain. Front Endocrinol (Lausanne) 2014 Mar 31;5:40. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978256/

[8] https://www.ncbi.nlm.nih.gov/pubmed/30853666