User:Hbf878/Protein crotonylation

Protein crotonylation is a type of posttranslational modification featuring the attachment of a crotonyl group (chemically derived from crotonic acid) to the ε-nitrogen of lysine residues. Lysine crotonylation (KCr) has been most studied in histones

Crotonylation occurs mainly on nuclear proteins !!10.1021/acs.jproteome.7b00012!!

In plants, protein crotonylation has mainly been detected in chloroplasts. !!10.1074/mcp.RA118.000640!!

p300 also has an intrinsic HCT activity in vitro and that it regulates histone H3 lysine 18 crotonylation (H3K18Cr) and H3K18 acetylation (H3K18Ac) in cells. !!10.1038/nrm3992!!