User:Heathurrr/sandbox

Intestinal Alkaline Phosphatase
Intestinal alkaline phosphatase is secreted by enterocytes, and seems to play a pivotal role in intestinal homeostasis and protection as well as mediation of inflammation via  repression of the downstream Toll-like receptor (TLR)-4-dependent and MyD88-dependent inflammatory cascade. It dephosphorylates toxic/inflammatory microbial ligands like lipopolysaccharides, unmethylated cytosine-guanine dinucleotides, flagellin, and extracellular nucleotides such as uridine diphosphate or ATP. Thus, altered IAP expression has been implicated in chronic inflammatory diseases such as IBD. It also seems to regulate lipid absorption and bicarbonate secretion in the duodenal mucosa, which regulates the surface pH.