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= Angiocentric glioma = Angiocentric glioma (AG) refers to a rare type of neuroepithelial tumor named after how the superficial brain tumor tissue is "hugging" or surrounding the brain vessels. Initially identified in 2005 by Lellouch-Tubiana’s team from...., AG then was classified as Grade I by 2007 WHO Classification of Tumors of the Central Nervous System due to its benign clinical behavior, low proliferation index and curative properties. AG primarily affects children and young adults with an average initial diagnosis age of 17 years. Over 95% of the patients diagnosed with AG experience intractable seizures since childhood, specifically partial epilepsy.

The etiology or exact mechanism remains unknown, yet a series of suspected causes are under discussion. Currently, while no definitive pathological tests are available to help identify this rare type of indolent glioma. The clinical agents use MRI (Magnetic Resonance Imaging) to diagnose AG, and find that it appears similar to low-grade glioma. In terms of therapy, the effect of radiation or chemotherapy is unclear. Patients often undergo subtotal or total resection to remove the problematic lesion and cure the disease. However, patients still require more extended follow-up periods after surgery for monitoring tumor recurrence and assuring seizure-free.

Signs and Symptoms
Patients usually experience a history of intractable seizures at 3 to 14 years old. The seizure severity often depends on the tumor locations rather than its size, as superficial lesions located in the frontal and temporal lobes often triggers a higher epileptogenic possibility than the deeper tumors. Common symptoms also include headache, vision impairment, dizziness, otalgia, ataxia and paresis, predominantly in children and young adults. The symptoms of low-grade, slow-growing gliomas are more epileptogenic, whereas the high-grade glioma manifests symptoms related to increased intracranial pressure.