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Genetic Matchmaking is the idea of matching couples for romantic relationships based on their biological compatibility. The initial idea was conceptualized by Dr. Wekekind through their famous "sweaty t-shirt" experiment. Males were asked to wear T-shirts for two consecutive nights, and then females were asked to smell the t-shirts and rate the body odors for attractiveness. Human body odor has been associated with the human leukocyte antigens (HLA) genomic region. They discovered that females were attracted to men who had dissimilar HLA alleles from them. Furthermore, these females reported that the body odors of HLA-dissimilar males reminded them of our current partners of ex-partners providing further evidence of biological compatible.

Evidence of biological compatibility
Following the seminal research done by Dr. Wekekind, several independent studies were done to further prove the concept of biological compatibility. Garver-Apgar et al. presented evidence for HLA_dissimilar alleles playing a factor in the healthiness of romantic relationships. They discovered that as the proportion of HLA-similar alleles increase between couples, females reported being less sexual responsive to their partners,, less satisfaction from being aroused by their partners and having additional sexual partners (while with their current partner). Additionally, Ober et al. conducted an independent study on a population of American Hutterites by comparing the HLA alleles of married couples. They discovered that married couples were less likely to share HLA alleles than expected by just random chance; Thus there results were consistent with the idea of HLA-disassortative mating preferences. Further evidence of the importance of genetic compatibility can be seen in research that shows that couples sharing a higher proportion of HLA alleles tend to have recurring spontaneous abortions, reduced body mass in babies , and longer internals between successive births.

Reasons for biological compatibility
There are several biological reasons why females would be attracted to and mate with men with dissimilar HLA alleles :


 * Their offspring would have a greater assortment of HLA alleles theoretically giving them a wider diversity of antigens to present on the surface of cells compared to HLA-homozygous offsprings. The wider variety of antigens allows the immune system to target a greater number of pathogens making the offspring more immunocompetent.
 * Any HLA allele which becomes a more resistant allele would not simply become an inherent allele in all individuals. Through  evolution, there will always be some pathogens who can become resistant to this allele, and spread to create a selection against this allele.  HLA-dissortative mating can be considered a method to cause the adaptations, that pathogens have to their host, obsolete in their offpsring;  In other words, allow us to keep up in the  "Red queen's race".
 * HLA genes are highly polymorphic between individuals. Any two individuals with similar HLA genes could be possibly related.  Mating of two related individuals would result in inbreeding which can be harmful to the offspring since it would result in a greater amount of genetic homozygosity thus increasing the chances of recessive mutations.

Commercialization of Genetic Matchmaking
Several commercial copies have arisen to pave the way for genetic matchmaking. Most notably are American-based ScientificMatch and Swiss-based GenePartner.

Criticism
There have been skepticism throughout the science community claiming the idea to be ridiculous. "They are just trying to make a buck," Dr. Rocio Moran, medical director of the General Genetics Clinic at the Cleveland Clinic. "If it's genetic, it must be real science." Many skeptics state that the science of love cannot be simplified to just a few a genes.