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Segregation analysis is a statistical method used to assess whether the distribution of phenotypes within families aligns with the inheritance of a major gene responsible for that trait. It is employed to identify Mendelian ratios in sibling groups or, more broadly, to ascertain the inheritance pattern of a specific phenotype using family data, with a focus on revealing the effects of a single gene.

Detecting of ROH
Chromosomal microarray analysis is one of the commonly used tools in the detection of chromosome uniparental disomy in prenatal diagnosis.

Generally, there are two methods used for the detection of ROH, tools like PLINK relies on a scanning window approach, it slides a window on the genome and count the number of heterozygous SNPs and missing SNPs at each window, the window with the number under the predefined maximum values

ROH in prenatal test
Dependenting on the length and distribution, ROHs may have different indications such as uniparental disomy, identity of descent, common ancestral markers in populations. As ROH smaller than 3 Mb spread throughout the genome are common even in outbred populations, these segments were usually thougut to be unimportant to be reproted.