User:Heinstar/

General Antidepressant Studies
SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex: https://www.nature.com/articles/mp2010138

BDNF — a key transducer of antidepressant effect: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763983/

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs: https://www.sciencedirect.com/science/article/pii/S0006295215001562

The Efficacy of Antidepressants in Alleviating Anhedonia in Depressed Patients: https://digitalcommons.butler.edu/cgi/viewcontent.cgi?article=1354&context=ugtheses

Antidepressant Rating Scales
Rating scales in depression: limitations and pitfalls: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181766/

Montgomery-Asberg Depression Scale: https://www.outcometracker.org/library/MADRS.pdf

Hamilton Depression Rating Scale: http://www.assessmentpsychology.com/HAM-D.pdf

SSRI efficacy
Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1173-2

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32802-7/fulltext

Hippocampus
Depression and the Hippocampus: Cause or Effect?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733566/

Major depression: a role for hippocampal neurogenesis?: https://www.ncbi.nlm.nih.gov/pubmed/22903751

What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?: https://www.ncbi.nlm.nih.gov/pubmed/17401728

The role of the hippocampus in the pathophysiology of major depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524959/

Depression, antidepressants, and the shrinking hippocampus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60045/

Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression: 20 years on: http://journals.sagepub.com/doi/abs/10.1177/0269881116661074

SSRI Pros
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/

Use of low-dose fluoxetine in major depression and panic disorder: https://www.ncbi.nlm.nih.gov/pubmed/8270588

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies: https://www.sciencedirect.com/science/article/pii/S0079612308009023

Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612120/

Serotonin receptors in depression: from A to B: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/

The serotonergic system and cognitive function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017596/

Effects of S-citalopram, citalopram, and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N-methyl-D-aspartate receptor-mediated transmission in the medial prefrontal cortex and cognitive function in the rat.: https://www.ncbi.nlm.nih.gov/m/pubmed/20730799/

SSRI Cons
SSRI-Induced Indifference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989833/

SSRI-induced apathy syndrome: a clinical review: https://www.ncbi.nlm.nih.gov/pubmed/15330228

Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674976/

Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002481/

SSRIs and cognitive performance in a working sample: https://www.ncbi.nlm.nih.gov/pubmed/16206235

Cognitive tolerability following successful long term treatment of major depression and anxiety disorders with SSRi antidepressants: https://www.ncbi.nlm.nih.gov/pubmed/25462418

Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54779/

New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal: https://www.karger.com/Article/FullText/371865

SSRIs: Bad to the Bone?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442753/

5-HT receptors
Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy: https://www.frontiersin.org/articles/10.3389/fnins.2010.00035/full

Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness: https://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-4-21

Transcriptional regulation of the 5-HT1A receptor: implications for mental illness: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405675/

Inhibitory Effect of Hippocampal 5-HT1A Receptors on Human Explicit Memory: https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.160.2.334

Effects of serotonin 2A/1A receptor stimulation on social exclusion processing: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983864/

The therapeutic role of 5-HT1A and 5-HT2A receptors in depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC446220/

Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression: https://www.sciencedirect.com/science/article/pii/S007961230800914X

Pharmacological Blockade of Serotonin 5-HT7 Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020210

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy: https://www.nature.com/articles/npp201113?foxtrotcallback=true

Dopamine agonist
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation: https://www.nature.com/articles/ncomms11829

Antidepressant properties of rotigotine in experimental models of depression: https://www.sciencedirect.com/science/article/pii/S0014299906007576

Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats: https://www.sciencedirect.com/science/article/pii/S0014299909005524

Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain: https://www.ncbi.nlm.nih.gov/pubmed/22023785

Antipsychotics
Second-generation antipsychotics for major depressive disorder and dysthymia: https://www.ncbi.nlm.nih.gov/pubmed/21154393

Alpha 2 adrenergic receptor
Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies: https://www.ncbi.nlm.nih.gov/pubmed/15363606

Other interesting studies
https://www.precisionbiotics.com/ie/zenflore-faqs

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30755-1

https://www.cell.com/fulltext/S0092-8674(16)31749-4

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050394/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753912/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601973/