User:Hhnguy32/Trepanning

Trepanning, also known as trepanation, trephination, trephining or making a burr hole (the verb trepan derives from Old French from Medieval Latin trepanum from Greek trypanon, literally "borer, auger") is a surgical intervention in which a hole is drilled or scraped into the human skull, exposing the dura mater, to treat health problems related to intracranial diseases or release pressured blood buildup from an injury.  Process of drilling (trephine), scraping (an abrasive instrument), or sawing  "burr" hole created through other body surfaces, including nail beds. It is often used to relieve pressure beneath a surface. A trephine is an instrument used for cutting out a round piece of skull bone.

In ancient times, holes were drilled into a person who was behaving in what was considered an abnormal way to let out what people believed were evil spirits. Evidence of trepanation has been found in prehistoric human remains from Neolithic times onward. The bone that was trepanned was kept by the prehistoric people and may have been worn as a charm to keep evil spirits away. Evidence also suggests that trepanation was primitive emergency surgery after head wounds to remove shattered bits of bone from a fractured skull and clean out the blood that often pools under the skull after a blow to the head. Hunting accidents, falls, wild animals, and weapons such as clubs or spears could have caused such injuries. Trepanations appear to have been most common in areas where weapons that could produce skull fractures were used. Most trepanation were performed on the left side due to the traumatic lesions were generally dealt by right-handed enemy.

There is some contemporary use of the term. In modern eye surgery, a trephine instrument is used in corneal transplant surgery. The procedure of drilling a hole through a fingernail or toenail is also known as trephination. I nvolving the exposure of the dura mater without damaging the underlying blood vessels, meninges, and brain. It is performed by a physician or surgeon to relieve the pain associated with a subungual hematoma (blood under the nail); a small amount of blood is expressed through the hole and the pain associated with the pressure is partially alleviated. In abdominal surgery, a trephine incision is when a small disc of abdominal skin is excised to accommodate a stoma. Although the abdominal wall does not contain bone, the use of the word 'trephine' in this context may relate to the round excised area of skin being similar in shape to a burr hole.

Prehistoric evidence
Trepanation is perhaps the oldest surgical procedure for which there is archaeological evidence, and in some areas may have been quite widespread. At one burial site in France dated to 6500 BCE, 40 out of 120 prehistoric skulls found had trepanation holes. Many prehistoric and premodern patients had signs of their skull structure healing, suggesting that many of those subjected to the surgery survived. Another skull with a trepanation hole was found at burial site Chalaghantepe (Agdam Rayon, Azerbaijan) dated to the 5th millennium BCE.

More than 1,500 trephined skulls from the Neolithic period (representing 5 to 10% of all Stone Age skulls) have been uncovered throughout the world –from Europe, Siberia, China and the Americas. Most of the trephined crania belong to adult males, but women and children are also represented. A cow skull dating to 3400-3000 BCE upon which trepanation had been performed was discovered in France.

Beside trephined skull found, other archaeological evidence include cave painting.

Pre-Columbian Mesoamerica
In the more recent times of postclassical pre-Columbian Mesoamerica, evidence for the practice of trepanation and an assortment of other cranial deformation techniques comes from a variety of sources, including physical cranial remains of burials, allusions in iconographic artworks and reports from the post-colonial period.

Among New World societies trepanning is most commonly found in the Andean civilizations, such as pre-Incan cultures. For example, the Paracas culture Ica, situated in what is now known as Ica, located south of Lima. It has also been found in the Muisca Confederation (in modern-day Colombia) and the Inca Empire. In both, even cranioplasty existed. Its prevalence among Mesoamerican civilizations is much lower, at least judging from the comparatively few trepanated crania that have been uncovered.

The archaeological record in Mesoamerica is further complicated by the practice of skull mutilation and modification carried out after the death of the subject, to fashion "trophy skulls" and the like of captives and enemies. This was a widespread tradition, illustrated in pre-Columbian art that occasionally depicts rulers adorned with or carrying the modified skulls of their defeated enemies, or of the ritualistic display of sacrificial victims. Several Mesoamerican cultures used a skull-rack (known by its Nahuatl term, tzompantli), on which skulls were impaled in rows or columns of wooden stakes. Even so, some evidence of genuine trepanation in Mesoamerica (i.e., where the subject was living) has survived.

The earliest archaeological survey published of trepanated crania was a late 19th-century study of several specimens recovered from the Tarahumara mountains by the Norwegian ethnographer Carl Lumholtz. Later studies documented cases identified from a range of sites in Oaxaca and central Mexico, such as Tilantongo, Oaxaca and the major Zapotec site of Monte Albán. Two specimens from the Tlatilco civilization's homelands (which flourished around 1400 BCE) indicate the practice has a lengthy tradition.

A study of ten low-status burials from the Late Classic period at Monte Albán concluded that the trepanation had been applied non-therapeutically, and, since multiple techniques had been used and since some people had received more than one trepanation, concluded it had been done experimentally. Inferring the events to represent experiments on people until they died, the study interpreted that use of trepanation as an indicator of the stressful sociopolitical climate that not long thereafter resulted in the abandonment of Monte Alban as the primary regional administrative center in the Oaxacan highlands.

Specimens identified from the Maya civilization region of southern Mexico, Guatemala and the Yucatán Peninsula show no evidence of the drilling or cutting techniques found in central and highland Mexico. Instead, the pre-Columbian Maya apparently used an abrasive technique that ground away at the back of the skull, thinning the bone and sometimes perforating it, similar to the examples from Cholula. Many skulls from the Maya region date from the Postclassic period (ca. 950–1400 CE), and include specimens found at Palenque in Chiapas, and recovered from the Sacred Cenote at the prominent Postclassic site of Chichen Itza in northern Yucatán.

Pre-modern Europe
Trepanation was also practiced in the classical and Renaissance periods. Hippocrates gave specific directions on the procedure from its evolution through the Greek age, and Galen also elaborates on the procedure. During the Middle Ages and the Renaissance, trepanation was practiced as a cure for various ailments, including seizures and skull fractures. Out of eight skulls with trepanations from the 6th to 8th centuries found in southwestern Germany, seven skulls show clear evidence of healing and survival after trepanation, suggesting that the survival rate of the operations was high and the infection rate was low.

In the graveyards of pre-Christian (Pagan) Magyars, archeologists found a surprisingly high frequency (12.5%) of skulls with trepanation, although more than 90% only partial (these served probably ritual purposes). The trepanation was performed on adults only, with similar frequencies for males and females, but increasing frequency with age and wealth. This custom suddenly disappeared with the Magyars' conversion to Christianity.

A small area near (modern) Rostov-on-Don, in southern Russia, may have been a centre for ritual trepanning, around 6000 years ago, according to archeologists who discovered remains of eight recipients of the practice, within a small area, all with the incision in the unusual obelion position, high on the back of the head.

Ancient China
Until as recently as 2007, archaeological evidence of trepanation in ancient China was nonexistent. Han and Chen from the Institute of Archeology, Chinese Academy of Social Sciences looked at six trepanned skulls spanning between the Neolithic period through the Bronze and Iron Ages (around 5000-2000 years ago) found in five different locations. These trepanned skulls showed cranial perforation in prehistoric China. Along with the discovery, another collection of 13 trepanned skulls were discovered and dated to 3,000 years ago. Most significantly, in 2015 discovery of a trepanned skull on an intact mummy dating 3600 years ago. The oldest trepanned skull (M382) in China was analyzed by Han and Chen. The M382 radiocarbon dated to around 5000 years ago (3000 BC - during the Neolithic period) was found in Fuija site in Guangrao, Shandong. The adult male skull shows a right parietal calvarial defect at 31 x 25 mm with evidence of scraping from the trephine-like tool. Evidence of bone regeneration and smooth edges suggesting the male subject recovered from surgery and lived a relatively long time before dying.

The 3600-year-old perforated skull of a mummified female dating to 1615 BC in the Xiaohe tomb in China's Xinjiang Uygur Autonomous Region. The only known female with a trepanned skull, shown signs of bone spurs growth, and retraction of the edges of trepanation openings suggests that she also survived the surgery. Found in a massive burial site, this mummy was among one of the hundreds found in the "Little River" Tomb complex.

The Bronze Age was found to be a period with the largest number of trepanned skulls in ancient China.

Modern medical practices
In the modern era, the use of trepanation is considered a pseudoscience. The prefrontal leucotomy, a precursor to lobotomy, was performed by cutting a trephine hole into the skull, inserting an instrument, and destroying parts of the brain. This was later made unnecessary by the development of the "orbital transit" lobotomy where a spike was inserted through the eye-sockets.

Trepanation is a treatment used for epidural and subdural hematomas, and for surgical access for certain other neurosurgical procedures, such as intracranial pressure monitoring. Although not illegal, many medical neurosurgeon refuse to perform trepanation for the concern of losing their medical license. Modern surgeons generally use the term craniotomy for this procedure. However, unlike our ancestors, craniotomy must be done after diagnostic imaging (which included computed tomography and magnetic resonance imaging) pinpointed the issues within the brain. The preoperative imaging allows for accurate examination and evaluation. The removed piece of skull is typically replaced as soon as possible. If the bone is not replaced, then the procedure is considered a craniectomy. Trepanation instruments, nowadays being replaced with cranial drills, are now available with diamond-coated rims, which are less traumatic than the classical trephines with sharp teeth. They are smooth to soft tissues and cut only bone. Additionally, the specially designed drills comes with safety feature prevents the drill from penetration into the brain tissue (through the dura matter) unintentionally. Along with antisepsis and prophylaxis of infection, modern neurosurgery is a common procedure in many reason other than head trauma.

Methods & Risks
As early as 7000 years ago, one of the alternative medicine practice was boring holes in each other's neurocranium with the aim not to kill but to cure. Similar to bloodletting, trepanation was carried out for both medical reasons and mystical practice.

In ancient times, trepanation instruments were less complex. Commonly made out of flint, obsidian, or harder material such as stone knives and later with metal such as bronze and copper. The trephination was performed by shamans or witch doctors utilizing tumi (ceremonial knife in early Peru), sharpened seashells (South Pacific), a trephine drill, bronze knife, etc. The Greeks were the first to use a drill-bore for the operation. By the Renaissance period, when trepanation was routinely performed, a range of instruments was developed to accommodate the demand such as trephine drills.

As many as five main methods were found for trephination. [2] The list includes (1) Rectangular intersecting cuts; (2) Scraping utilizing an abrasive instrument such as flint; (3) circular grooving; (4) boring and cutting by a circular trephine or crown saw; (5) drill several circle holes closely to create a space and then cut/chisel the bone between the hole. Scaping method was found to be the most common in prehistoric crania.

The procedure comes with severe repercussions such as increase damage to the brain, the risk of infection, and potentially death due to the trauma as the skull's protective covering is compromised. The operation leaves for a very minimal space for error and a high incidence of mortality if penetrate the dura mater. Additionally, if conduct with contaminated tools and improper sanitary of wound care can lead to a high risk of infection. If the infection is not caught and treated immediately, it can be fatal or lead to significant and permanent brain damage. After surgery, hyperemia and osteoclastic activity are seen as the necrotic bone surround the trepanation site due to loss of blood supply.

The perforations were found with growth of fine bone spurs indicates that trepanation had been carried out on live subject than being a ritual conducted after death. There are evidences that some individuals survived multiple skull surgeries. With evidence of bone remodeling around the skull defects, corroborated by the smooth borders around the opening, sealed by a dense cortex of bone, denoting procedural success after trepanation and term of survival. Furthermore, the survival rate of the operations was higher than expected and the infection rate relatively low. However, several skulls also show the risk of the operation with some indicates stopping mid-operation as the trephining is incomplete.

The operation hopes to increase the elastic properties of the skull by the opening, allowing for the increase of the arterial pulse input.

Voluntary trepanation
The practice of trepanning also continues today due to belief in various pseudoscientific medical benefits. Some proponents claim that trepanning results in increased blood flow. Individuals have practiced non-emergency trepanning for psychological purposes. A prominent proponent of the modern view is Peter Halvorson, who drilled a hole in the front of his own skull to increase "brain blood volume".

One of the most prominent advocates of trepanning was Dutch librarian Bart Huges. In 1965, Huges drilled a hole in his own head with a dentist drill as a publicity stunt. Huges claimed that trepanning increases "brain blood volume" and thereby enhances cerebral metabolism in a manner similar to cerebral vasodilators such as ginkgo biloba. These claims are unsubstantiated by research. Huges and his girlfriend also made several comic books in the 1970s, which promoted trepanation.

In a chapter of his book Eccentric Lives & Peculiar Notions, esotericist John Michell cites Huges as pioneering the idea of trepanning in his 1962 monograph, Homo Sapiens Correctus, which is often cited by advocates of self-trepanation. Among other arguments, Huges contends that children have a higher state of consciousness and since children's skulls are not fully closed, one can return to an earlier, childlike state of consciousness by self-trepanation. Further, by allowing the brain to freely pulsate Huges argues that a number of benefits will accrue.

Michell quotes Joey Mellen's book, Bore Hole. At the time the passage below was written, Joey and his partner, Amanda Feilding, had made two previous attempts at trepanning Mellen. The second attempt ended up placing Mellen in the hospital, where he was reprimanded severely and sent for psychiatric evaluation. After he returned home, Mellen decided to try again. He describes his third attempt at self-trepanation:"After some time there was an ominous sounding schlurp and the sound of bubbling. I drew the trepan out and the gurgling continued. It sounded like air bubbles running under the skull as they were pressed out. I looked at the trepan and there was a bit of bone in it. At last!"Feilding also performed a self-trepanation with a drill, while Mellen shot the operation for the short film "Heartbeat in the Brain", which was long thought to have been lost. Portions of the film can be seen in the documentary A Hole in the Head.

Michell also describes a British group that advocates self-trepanation to allow the brain access to more space and oxygen. Other modern practitioners of trepanation claim that it holds other medical benefits, such as a treatment for depression or other psychological ailments. In 2000, two men from Cedar City, Utah, were prosecuted for practicing medicine without a license after they performed a trepanation on an English woman to treat her chronic fatigue syndrome and depression.