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Brunner's Glands First discovered by Swiss anatomist John Conrad Brunner in 1687. Only found in mammals. Brunner's glands are located in the submucosa of the duodenum and can extended throughout the small intestine. The presences stops at the sphincter of the Oddi. The main function of Brunner's Glands is to produce alkaline mucous. The mucous aides in digestion, and helps with lubrication. The disease hyperplasia can affect Bruner's Glands, but is extremely rare.