User:Hodik g/Gad Glaser

Gad Glaser (born 1939) is an Israeli physician and scientists. He served twice as the Dean of the Faculty of Medicine at the Hebrew University in Jerusalem, Dean of the Koret School of Veterinary Medicine, and the CEO of the Hebrew University Veterinary Hospital. He is a senior academic advisor for youth research projects at the Bloomfield Science Museum Jerusalem  His research focuses mostly on gene expression regulation in bacteria.

Biography
Glaser was born in 1939 in Givat Brenner, the son of Dr. Moshe Glaser, the Kibbutz physician, and Gerti Glaser (Geiger), the granddaughter of Dr. Ludwig Moritz Philipp Geiger - the son of R' Dr. Abraham Geiger, A.B.D. He earned his medical degree at the Hebrew University where he also completed his PhD. In 1957 he was recruited to the Golani Brigade and in 1968 he joined as military physician to the Israeli Paratroopers Brigade reserve forces, where he participated in the War of Attrition, the Yom Kippur War in 1973, including the Battle of the Chinese Farm, as well as the Lebanon War of 1982.

He lives in Tel-Aviv with his wife Tamar, the former Chief Nursing Officer of Hadassah Medical Center.

Research
His early work at the Prof. Jacob Mager Lab at the Hebrew University focused on the chemistry of Glucose-6-phosphate dehydrogenase deficiency (G6PDD) -inducing compounds, such as broad beans (e.g., fava beans) that contain high levels of vicine, divicine, convicine and isouramil, all of which create oxidants and subsequent hemolytic anemia.

Further, he joined Prof. Eliezer Rachmilewitz in his research of Thalassemia and the development of early genetic screening tests. His work with Charles Michael Cashel, M.D.,Ph.D who identified in the 1960's the chemical composition of the spot compounds contained analogs of GDP and GTP with a pyrophosphorylated ribosyl 3' hydroxyl or (p)ppGpp. They have shown that Escherichia coli,regulatory effects are gene-specific through rRNA, but with both inhibitory and stimulatory components. Subsequently he has characterized Ribosomal genes in Mycoplasma pneumoniae.

In the 1990's Prof. Glaser has pioneered the research of Addiction module or toxin-antitoxin systems that consist of a pair of genes that specify two components: a stable toxin and an unstable antitoxin that interferes with the lethal action of the toxin. An early Addiction module was described with Engelberg-Kulka and others in Escherichia coli chromosome that included the mazF specifies for a stable toxin, and mazE specifies for a labile antitoxin, that antagonizes MazF. These systems are responsible for programmed cell death in E. coli and thus may have a role in the physiology of starvation.