User:Htafer/SNORA53

The snoRNA ACA53 belongs to the H/ACA family of pseudouridylation guide snoRNAs. This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. RNA residues targeted for pseudouridylation by this molecule have not been identified. It has a length well above 200nt, which is exceptionally large for an otherwise inconspicuous box H/ACA snoRNA.

Experimental surveys for snoRNAs have uncovered SNORA53 homologs in human , rhesus , platypus (Oa1744) , and chicken (GGN66) . Orthologous sequences across the tetrapoda are reported in the snoOPY database. SNORA53 is one of the most divergent snoRNAs in both sequence and structure. Our systematic survey records SNORA53 sequences throughout the metazoa. Across deuterostomes, it is located in an intron of the highly conserved mitochondrial phosphate carrier SLC53A3. The Strongylocentrotus purpuratus candidate contains an insert almost 1700 nt in length. It remains unclear, however, whether this is an artifact in the genome assembly.