User:Huibing Tan/sandbox/Megeloneurite

Megaloneurite is a specialized neurodegenerative structure revealed by NADPH diaphorase (N-d) histology in the sacral spinal cord of aged dog. The megaloneurite was also termed as meganeurite ( Yinhua Li, et al, 2019). Megaloneurites are distributed in the dorsal root entry zoon, Lissauer's tract, Lateral colateral pathway, intermedialateral nucleus, dorsal commissural nucleus, interior or exterior around the central canal and the white matter of lateral fasciculus. Pelvic organs are innervated by the lumbosacral spinal cord. N-d positive neurons and fibers also distributed in the pelvic organs. The aging-related dysfunction of the pelvic organs are incontinence, constipation and erectile dysfunction.

Yinhua Li, Yunge Jia, Wei Huo, Zichun Wei, Xiaoxin Wen, Yu Tian, Weijin Zhang, Bai Lu, Anchen Guo, Guanghui Du, Huibing Tan. De novo aging-related meganeurites: alteration of NADPH diaphorase positivity in the sacral spinal cord of the aged dog. doi: https://doi.org/10.1101/483990