User:Huskiesonthree/Choose an Article

Article Selection
Please list articles that you're considering for your Wikipedia assignment below. Begin to critique these articles and find relevant sources.

Option 1

 * Article title
 * - Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
 * Article Evaluation
 * - The goal of this study was to determine the relationship between repeated head injury exposure, neuroinflammation, and the development of hyperphosphorylated tau pathology and dementia risk in chronic traumatic encephalopathy. To quantify their study, they counted activated microglia, astrocytes, and ptau pathology in the dorsolateral frontal cortex (DLF). Found that a binary logistic regresson pointed towards a higher likelihood of being diagnosed with dementia if the pateint had a higher CD68 cell density, however, did not prove significant when hyperphosphorylated tau was included in the study. Concluded that repeated head impacts can be associated with chronic activation of microglia which can mediate the development of dementia in a patient with CTE.
 * Sources
 * - Acta neuropathologica communications 2016

Option 2

 * Article title
 * -The Association Between Persistent White-Matter Abnormalities and Repeat Injury After Sport-Related Concussion.
 * Article Evaluation
 * -Athletes were observed and tested shortly after injury (less than 48 hours), seven days after returning to their sport and six months after the initial injury. Average mean diffusivity was calculated in a region of the brain. Using a binary logistic regression, the likelihood of getting another concussion over a one year period was studied. Found that 11 of the 82 concussed athletes in the study re-injured themselves via concussion less than one year after their first injury. Concluded that average mean diffusivity at seven days post returning to play and the likelihood of suffering a repeated injury was very near significant.
 * Sources
 * - Frontiers in Neurology 2020

Option 3

 * Article title
 * -Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study.
 * Article Evaluation
 * -Medial temporal lobe (MTL) tissue form postmortum brains were immunolabeled using an early or late moarker for pathological tau and for amyloid beta. Stereological analysis was used to see if differnet stages of CTE had different levels of neuronal damage. Found that the most severe tau pathology was located in hippocampal CA1, CA3 and sub. The researchers also confluced that a chronic truamatic encephalopathy stage increase across all medial temporal lobe tissues examined.
 * Sources
 * -Acta Neuropathologica Communications 2019

Option 4

 * Article title
 * -Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study.
 * Article Evaluation
 * -Participants (collegiate athletes) completed clinical assessments and DTI at 4 time points following a head injury. White matter areas with abnormalities were studies and linear mixed models were used to study longitudinal changes. DTI derived mean diffusiviity was significantly higher in the white matter of athletes that suffered a concussion at 24 to 48 hours after injury. No significant metrics in DTI were observed between contact and non contact sport athlete controls.
 * Sources
 * -Neurology 2020

Option 5

 * Article title
 * -Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme
 * Article Evaluation
 * -The goal of this study was to test the applicability of the McKee CTE staging scheme in order to provide an examination of the regional distribution of p-tau in CTE. Found a higher affinity for p-tau (hyperphosphorylated tau) in five regions of the brain: dorsolateral frontal cortex (DLF), superior temporal cortex, entorhinal cortex, amygdala, and locus coeruleus (LC). These findings confirm the McKee test is valuabe.
 * Sources
 * -Acta Neuropathologica 2020