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=Emmanuel JM Mignot=

Emmanuel JM Mignot (born 1959, in Paris) is a US sleep researcher and director of the Stanford Center for Sleep Sciences and Medicine, at Stanford University. He is a leading authority on sleep research and medicine, and is mostly known for his work on narcolepsy.

Early life
Mignot was born in Paris, France. He completed his Science Doctorate in Molecular Pharmacology at the Université Pierre and Marie Curie and went to medical school at Necker-Enfants Malades, Université René Descartes, with subspecialisation in Psychiatry. Dr. Mignot is a former student of the prestigious Ecole Normale Superieure (Ulm).

Marriage and Offspring
Mignot married Servane Briand (born 1964) and has two sons: Xavier Mignot (born 1994) Samuel Mignot (born 1996)

Expended description
Following a postdoctoral fellowship at the Stanford Sleep Center, Mignot felt that understanding narcolepsy could lead to breakthrough in new understanding of sleep. He was appointed Assistant Professor of Psychiatry and Behavioral Sciences at Stanford University in 1993, Professor in 2001 and Director of the Center for Sleep Sciences and Medicine in 2011, succeeding William C Dement. Trained as a pharmacologist, he first deciphered the mode of action of modafinil, amphetamines and antidepressants on narcolepsy symptoms, work that was done in close collaboration with Dr. Seiji Nishino.

Starting in 1990, he decided to isolate the gene causing narcolepsy in Doberman and Labradors. Ten years later, this led to the discovery that mutations in the hypocretin/orexin receptor 2 cause canine narcolepsy, and that human narcolepsy was caused an immune mediated destruction of the hypocretin (orexin) producing cells in the brain Parallel work performed by Mashashi Yanagisawa, Christopher Stinton and colleagues subsequently showed that hypocretin (orexin) deficient mice also have narcolepsy.

The autoimmune destruction of hypocretin (orexin) neurons in the hypothalamus was later shown by Han and Mignot to be at least partially precipitated by influenza A infections, notably the H1N1 2009 pandemic strain, complementing findings made in Northern Europe following the H1N1 Pandemrix vaccination campaign.

Dr. Mignot identified genetic factors predisposing to human narcolepsy, such as Human Leukocyte Antigen HLA DQB1*06:02 and other genes and isolated the gene causing the methylopathy Autosomal Dominant Cerebelar Ataxia, Deafness and Narcolepsy (ADCA-DN), DNMT1.

Awards
Dr. Mignot has received numerous research grants and honors, including National Sleep Foundation and National Institute of Health Research Awards, Howard Hughes Medical Institute Investigator and McKnight Neuroscience awards, the Narcolepsy Network professional service award, the Drs. C. and F. Demuth 11th Award for Young Investigators in the Neurosciences, the WC Dement Academic Achievement Award in sleep disorders medicine, the CINP and ACNP awards in neuropharmacology and the Jacobaeus prize. He is an elected member of the Association of American Physicians and of the Institute of Medicine of the National Academy of Sciences. He is the co-author of more than 200 original scientific publications, and he serves on the editorial board of scientific journals in the field of sleep and biology research. Dr. Mignot is an active member of several professional and governmental organizations. He has been past president of the Sleep Research society, chair the National Center on Sleep Disorders Research Advisory board of the National institutes of Health and chair of the Board of Scientific Counselors of the National Institute of Mental Health.

Published work
Selected articles can be found on his webpage

A more complete list can be found on Pubmed (search "Mignot E" or "Mignot sleep")]

See also: Narcolepsy and Hypersomnia, Claudio Bassetti (Editor), Michel Billiard (Editor), Emmanuel Mignot (Editor), 736 pages, Informa Healthcare; 1 edition (Dec 21 2006), English, ISBN-10: 0849337151, ISBN-13: 978-0849337154

External Link
Stanford Center for Sleep Sciences and Medicine