User:IEDITES/Elias A. Said

Born in Aleppo

Elias A. Said is an Associate Professor in the Department of Microbiology and Immunology, College of Medicine and Health Sciences in the Sultan Qaboos University. He is an editor and reviewer for several scientific journals. He performed his Ph.D. in “Institut Pasteur” in Paris and Paris 7 (Paris Cité) University. He was a Post-Doctoral Researcher and Research Associate in the University of Montreal Hospital Research Centre (CR-CHUM). His research focuses on cytokines and innate immunity (innate APCs and TLRs, etc.) especially in viral infections.

- Demonstrated the differential production of the cytokines and growth factors midkine and pleiotrophin by human innate antigen presenting cells (APCs).

- Demonstrated that cell-surface nucleolin is the low affinity receptor of midkine and pleiotrophin.

- Discovered sequences in hepatitis C virus (HCV) genomic RNA that stimulate the innate immunity via Toll-like receptors (TLRs) 7 and 8.

- Identified a role for the protein PD-1 present on monocytes (HIV infection).

- Defined for the normal levels (reference range) of interleukin-6 (IL-6) in the human blood.

- Demonstrated the capacity of HCV to avoid the proper stimulation of the innate immune system.

- Demonstrated that APCs can control endothelial cells proliferation through midkine.

- Demonstrated that the innate immune cells in the liver have an inhibitory and a biased profile in HCV and HBV infections, respectively.

- Documented that sleep deprivation affects some immune components.

He also participated in the identification of an HIV domain that can elicit neutralizing antibodies and thus constitutes a vaccine candidate and the demonstration of the importance of PD-1 as a target to revert the exhaustion of T-lymphocytes in humans.

Nature Medicine, Nature Medicine,  Nature Medicine,  Cell / Immunity,  Journal of Experimental Medicine,  Journal of Biological Chemistry,    مصادر