User:IONTRANSP

I'm interested in ion transport.

Chloride channel

 * ANO1 Chloride Channels: Often enigmatic, rarely predictable

Sodium–hydrogen antiporter 3

 * Role of NH3 and NH4+ transporters in renal acid-base transport
 * Luminal Na+/H+ exchange in the proximal tubule

Voltage-gated proton channel

 * Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T

voltage-sensor containing phosphatase

 * Voltage-sensing phosphatase: actions and potentials

Parkinson disease
LRRK2 G2019S accounts for parkinsonism in several families

There is a functional interaction between LRRK2 and ADP-ribosylation factor GTPase-activating protein 1 (ArfGAP1)

Unlike other known genetic causes of parkinsonism, G2019S LRRK2 mutation causes late onset disease

G2019S LRRK2 mutation is associated with Lewy body formation which is also characteristic of most cases of Parkinson disease

PARK8-causing mutations in LRRK2. Some of the first identified individuals with these mutation were of Basque descent so the protein was called "dardarin" after the Basque word ("dardara") for "tremor".

COR domain mutation analysis for LRRK2.

LRRK2 dimerization

Databases

 * Orientations of Proteins in Membranes database