User:Ian Kates/VLDL Receptor Project

Introduction
This is the project proposal for the creation of the Wikipedia page for the VLDL receptor (Very Low Density Lipoprotein Receptor). This project for BI481 Introduction to Neuroscience to help expand the field of neuroscience for the Society for Neuroscience.

Members working on this project: Ian Kates, Katie Czepiel, and Jennifer Goldberg.

The project page can be found here.

Topics to Cover

 * Function
 * Role in the nervous system
 * Systems it affects, or is present in


 * Structure
 * Protein structure
 * Genetic basis of structure


 * Protein Biosythesis
 * subcellular localization
 * Genetic variants and mutations


 * Mechanism and Interactions
 * Transport mechanism
 * Result of ligand binding
 * Inhibitors
 * Positive and negative feedback control


 * Associated Conditions and Diseases
 * Bipolar disorder, schizophrenia, Parkinson's
 * Genetic mutation of VLDL receptor gene


 * Clinical Research


 * References

Division of Work
This is the planned division of work. This will be subject to change depending on the amount of work that is needed to complete each topic and the amount of information available.

Ian Kates: Protein structure, genetic basis of structure, Inhibitors, Positive and Negative feedback control, Clinical Research

Katie Czepiel: Tranport mechanism, Result of ligand binding, Associated Diseases(Parkinson's)

Jennifer Goldberg: Role in nervous system, Systems it affects or is present in, Genetic mutation of VLDL-R gene, Associated Diseases (Schizophrenia and Biopolar disorder)

Current Articles and Information
VLDL receptor structure.

LDL protein mediated neurite growth in CNS.

Physiological role of LDL receptor family.

VLDLR role in corticol neuron migration.

VLDLR role in neuronal migration mechanisms in development and disease.

Lissencephaly with cerebellar hypoplasia (LCH).

Neuronal Migration.

VLDLR Types.

Type I lissencephaly.

Structure 1.

Structure 2.

VLDLR Expression.

Discovery in 1992.

Cerebellar Hypoplasia.