User:Immcarle1

Assignment 6
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Assignment 4 Update
Topic Choice: IL-17

This cytokine is released by T Helper cell 17. Specifically it plays a role in both the adaptive immune system and pathogenesis of the autoimmune disorder psoriasis. I plan to discuss the role of IL-17 in the pathogenesis of psoriasis. IL-17 is considered the primary cytokine involved in potentiating this autoimmune disorder. I want to discuss the signaling cascade and other cell types IL-17 interacts with to produce psoriasis.

Sources: Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis (2011), Immunology of Psoriasis (2014), The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings (2012), IL-17 receptor and its functional significance in psoriatic arthritis (2012), Role of IL-17 in Psoriasis and Psoriatic Arthritis (2013), IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis (2012)

Immcarle1 (talk) 07:54, 9 February 2016 (UTC)