User:Immcarle116/Macrophage-1 antigen

- iC3b generated by proteolysis of C3b

- Integrin α chain (CD11b) noncovalently bound to integrin β chain (CD18).

- phagocytosis of microbes opsonized with iC3b

- can bind to ICAM-1 on endothelium cells?

1. Erdei et al. (2019)

- members of the β2-integrin (CD18)

- "β2-integrins are accepted to play important roles in cellular adhesion, migration, phagocytosis, ECM rearrangement and inflammation."

- Expression levels and other functional differences in mice and men assessed

2. Vorup-Jensen & Jensen (2018)

- Analysis of structural CR3

- CR3 and CR2 work together to become an antigen presenting mechanism

- MIDAS

- "CR3 as inclined to bind positively charged species"

- CR3 and CR4 in NK --> complement-dependent cell cytotoxicity --> biological therapy

3. Rotshenker (2003)

- Regulation of complement-receptor-3

- Injury and disease in CNS and PNS?

- "CR3/MAC-1-mediated myelin phagocytosis is regulated in microglia and macrophages"

4. van Lookeren Campagne et al. (2007)

- "C3b is further degraded to iC3b, C3c and C3dg, products that serve as ligands for selective complement receptors on leukocytes."

- Other useful background

5. Ross & Vĕtvicka (1993)

- intercellular adhesion molecule-1 (ICAM-1)

- LPS binding (PRR)

6. Roberts et al. (2016)

- "Leukadherin‐1 is a specific small‐molecule CR3 agonist that has shown therapeutic promise in animal models of vascular injury and inflammation."

7. Doz-Deblauwe et al. (2019)

- CR3 engaged by PGL-I promotes infection.

8. Agramonte‐Hevia et al. (2006)

- Gram-negative bacteria interaction with phagocytic cells through CR3.

- "Bordetella takes advantage of the CR3 function and uses it to enter into macrophages leading to bacterial survival."

9. Tanya & Mayadas (2016)

- "pro-inflammatory molecule"

- immunoregulatory roles