User:Immcarle181/GNLY

9 kDa GNLY
The 9 kDa form functions as a pore-forming protein, as it is able to permeabilize cell membranes. The 9kDa form can cytolyze fungi, yeast, parasites, gram negative, and gram positive bacteria. This protein is also far more effective in targeting bacterial membranes than mammalian membranes, though it can target many different cell types, such as those from fungi and parasites. The 9 kDa form is also inhibited by cholesterol which is present in usually present in mammalian cells, but not in most pathogen cells. This all makes GNLY 1000 times less effective in pore formation in human cells than in microbe cells. However, the precise mechanisms of pore formation is not yet fully understood.