User:Immcarle66/sandbox

VLA-4
 * All of the VLA-4 article information is relevant, nothing was distracting. However, the problem is that there isnt enough information. There is only 3 paragraphs.
 * I think the article is neutral. It is scientific.
 * There are no over or underrepresented viewpoints.
 * There are only two citations. One doesn't even have a link. This needs updating.
 * There is information in the beginning not cited. The citations available appear to be reputable.
 * There needs to be more information about the basic function of the integrin. I think the medical information could be in a separate header.
 * There is no conversation.
 * The article is a stub. It is "low importance."
 * We have yet to review this in class. I think one would need a background on leukocytes.

Notes from Essential Roles of VLA-4 in Hematopoietic System (Yoichi Imai, Motomu Skimaoka, and Mineo Kurokawa)

-VLA-4 is expressed on stem cells, progenitor cells, T and B cells, monocytes, Natural Killer cells, eosinophils, and neutrophils

-IL-4 downregulates VLA-4 expression on T cells

-VLA-4 is essential for the stem cells that localize to the liver of fetuses and the hematopoietic organs of adults

-VCAM-1 and fibronectin are the main ligands

-VLA-4 responsible for progenitor cells getting to the bone marrow

-the chemokine SDF-1 is responsible for the conformational change of VLA-4 which increases its affinity through the two domains changing their conformation

-there is a possibility for therapy of stem cells by stimulating the conformational change