User:Indraneel.mittra/sandbox

Professor Indraneel Mittra is Dr. Ernest Borges Chair in Translational Research and Professor Emeritus, Department of Surgical Oncology at Tata Memorial Centre / Advanced Centre for Treatment, Research and Education in Cancer (ACTREC). Professor Mittra [born 28 June 1943] obtained his medical degree from University of Delhi and did his Post Graduate Training in Surgery in the UK to become a fellow of the Royal College of Surgeons of England. He obtained his Ph.D. degree from University of London and did his post-doctoral work with Dr. Renato Dulbecco, Nobel Laureate, at the Imperial Cancer Research Fund Laboratories in London.

On returning to India in 1982, Professor Mittra joined the Tata Memorial Hospital, Mumbai as a Consultant Surgeon in the Department of Surgical Oncology where he established India’s first dedicated Breast Unit and became the Chief of the Service. Professor Mittra simultaneously established the Division of Laboratory Medicine at TMH which he headed for 20 years.

Professor Mittra has published widely in the fields of clinical, basic and public health research in cancer in major international journals. He happens to be the first and only Indian investigator to have received a RO-1 grant from the US NIH to conduct one of the largest public health randomized trials of screening for breast and cervical cancer. Professor Mittra has the distinction of having published his first ever scientific contribution as a single author paper in Nature in 1974. Professor Mittra was conferred the Roll of Honours by the International Union Against Cancer in 1994. He has been visiting professor to several international institutions and held the Prestigious Pearce Gould Professorship at University College London in 1998.

Professor Mittra is / has been on the editorial / advisory board of British Medical Journal, Lancet Oncology, Nature Clinical Practice Oncology, British Journal of Cancer, European Journal of Cancer, International Journal of Surgery, The Breast and Journal of Biosciences.

Professor Mittra is a fellow of the Indian Academy of Sciences and Indian National Science Academy.

Research
Professor Mittra's research interests are wide ranging and encompass clinical, laboratory and public health research in cancer as evidenced by his diverse publications in these fields. Professor Mittra’s public health research on cancer early detection using low cost technology approaches has established for the first time that visual inspection of the cervix using 4% acetic acid reduces mortality from cervical cancer by 31%. This research finding if applied widely can save nearly 200,000 lives globally every year. Results of the breast cancer component of this study will be released in 2016.

In 2009, Professor Mittra established the Translational Research Laboratory at ACTREC, the research wing of Tata Memorial Centre. His current laboratory research interest is in the area of biology of extracellular nucleic acids and their role in cancer initiation and metastasis. Professor Mittra’s research has led to the discovery that circulating nucleic acids are biologically active molecules and are freely taken up by healthy cells of the body. The intracellular nucleic acids integrate into host-cell genomes and cause damage to their DNA. These findings signal a new dawn in biology and have far-reaching implications for ageing and a multitude of human pathologies including initiation and metastasis of cancer.

Selected Publications
1. Mittra I, Khare NK, Raghuram GV, Chaubal R, Khambatti F, Gupta D, Gaikwad A, Prasannan P, Singh A, Iyer A, Singh A, Upadhyay P, Nair NK, Mishra PK, Dutt A. 2015. Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes. J Biosci. 40(1):91-111.

2. Shastri SS, Mittra I, Mishra GA, Gupta S, Dikshit R, Singh S, Badwe RA. 2014. Effect of VIA screening by primary health workers: randomized controlled study in Mumbai, India. J Natl Cancer Inst. 106(3):dju009. doi: 10.1093/jnci/dju009.

3. Rekha MR, Pal K, Bala P, Shetty M, Mittra I, Bhuvaneshwar GS, Sharma CP. 2013. Pullulan-histone antibody nanoconjugates for the removal of chromatin fragments from systemic circulation. Biomaterials. 34(27):6328-38. doi:10.1016/j.biomaterials.2013.05.019.

4. Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Medeiros Alencar VH, Badran A, Bonfill X, Bradbury J, Clarke M, Collins R, Davis SR, Delmestri A, Forbes JF, Haddad P, Hou MF, Inbar M, Khaled H, Kielanowska J, Kwan WH, Mathew BS, Mittra I, Müller B, Nicolucci A, Peralta O, Pernas F, Petruzelka L, Pienkowski T, Radhika R, Rajan B, Rubach MT, Tort S, Urrútia G, Valentini M, Wang Y, Peto R; Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. 2013. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 381(9869):805-16. Erratum in: Lancet. 2013; 381(9869):804.

5. Badwe R, Hawaldar R, Parmar V, Nadkarni M, Shet T, Desai S, Gupta S, Jalali R, Vanmali V, Dikshit R, Mittra I. 2011. Single-injection depot progesterone before surgery and survival in women with operable breast cancer: a randomized controlled trial. J Clin Oncol. 29(21):2845-51. doi:10.1200/JCO.2010.33.0738.

6. Mittra I. 2009. Why is modern medicine stuck in a rut? Perspect Biol Med. 52(4):500-17. doi: 10.1353/pbm.0.0131.

7. Mittra I, Mishra GA, Singh S, Aranke S, Notani P, Badwe R, Miller AB, Daniel EE, Gupta S, Uplap P, Thakur MH, Ramani S, Kerkar R, Ganesh B, Shastri SS. 2010. A cluster randomized, controlled trial of breast and cervix cancer screening in Mumbai, India: methodology and interim results after three rounds of screening. Int J Cancer. 126(4):976-84. doi: 10.1002/ijc.24840.

8. Mittra I. 1997. Clinical cancer trials in developing countries. Lancet. 349(9047):290.

9. Baum M, Vaidya JS, Mittra I. 1997. Multicentricity and recurrence of breast cancer. Lancet. 349(9046):208.

10. Bhattacharya D, Redkar A, Mittra I, Sutaria U, MacRae KD. 1997. Oestrogen increases S-phase fraction and oestrogen and progesterone receptors in human cervical cancer in vivo. Br J Cancer. 75(4):554-8.

11. Chakravarty G, Redkar A, Mittra I. 1996. A comparative study of detection of p53 mutations in human breast cancer by flow cytometry, single-strand conformation polymorphism and genomic sequencing. Br J Cancer. 74(8):1181-7.

12. Vaidya JS, Vyas JJ, Chinoy RF, Merchant N, Sharma OP, Mittra I. 1996. Multicentricity of breast cancer: whole-organ analysis and clinical implications. Br J Cancer. 74(5):820-4.

13. Childhood ALL Collaborative Group. 1996. Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12000 randomised children. Lancet. 347(9018):1783-8.

14. Mittra I. 1994. Breast screening: the case for physical examination without mammography. Lancet. 343(8893):342-4.

15. Mittra I, MacRae KD. 1991. A meta-analysis of reported correlations between prognostic factors in breast cancer: does axillary lymph node metastasis represent biology or chronology? Eur J Cancer. 27(12):1574-83.

16. Mittra I, Badwe RA, Desai PB, Yeole BB, Jussawalla DJ. 1989. Early detection of breast cancer in developing countries. Lancet. 1(8640):719-20.

17. Mittra I. 1984. Somatomedins and proteolytic bioactivation of prolactin and growth hormone. Cell. 38(2):347-8.

18. Mittra I. 1980. A novel "cleaved prolactin" in the rat pituitary: Part II. In vivo mammary mitogenic activity of its N-terminal 16K moiety. Biochem Biophys Res Commun. 95(4):1760-7.

19. Mittra I. 1980. A novel "cleaved prolactin" in the rat pituitary: part I. Biosynthesis, characterization and regulatory control. Biochem Biophys Res Commun. 95(4):1750-9.

20. Mittra I, Perrin J, Kumaoka S. 1976. Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer. Br Med J. 1(6004):257-9.

21. Mittra I, Hayward JL, McNeilly AS. 1974. Hypothalamic-pituitary-prolactin axis in breast cancer. Lancet. 1(7863):889-91.

22. Mittra I, Hayward JL. 1974. Hypothalamic-pituitary-thyroid axis in breast cancer. Lancet. 1(7863):885-9.

23. Mittra I. 1974. Mammotropic effect of prolactin enhanced by thyroidectomy. Nature. 248(448):525-6.

Awards and honors
1. Fellow, Indian National Science Academy.

2. Fellow, Indian Academy of Sciences.

3. Pearce Gould Visiting Professor, University College London Medical School, 1999.

4. Conferred the Roll of Honors of the International Union Against Cancer 1994.