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ISTITUTO NAZIONALE DI GENETICA MOLECOLARE www.ingm.org

The Istituto Nazionale di Genetica Molecolare (INGM) is a no-profit research foundation aimed at the discovery and initial development of new therapies and new diagnostics in the fields of tumors and autoimmune diseases.

INGM will be located inside the campus of the IRCCS Ospedale Maggiore in Milan, in a new dedicated building (Padiglione Enrica Pessina e Romeo Invernizzi) the construction of which is being financed with a very generous donation of the late Enrica Pessina e Romeo Invernizzi and is foreseen to be completed within the end of 2010.

INGM comes to life to be a “translational” medical Research Institute that creates scientific knowledge capable of generating value on the basis of the intellectual property that ensues from its research activities. To achieve these objectives, INGM will develop scientific research strongly connected with clinics, drawing benefit from being located inside one of the most important European hospitals, the IRCCS Ospedale Maggiore of Milan. Research activities are coordinated by a Chief Scientific Officier with scientific and managerial expertise who is supported by a Scientific Advisory Board composed by researchers having a high international profile.

The INGM Foundation was established by the Italian Ministry of Health, the Ministry of Foreign Affairs, the IRCCS Ospedale Maggiore of Milan and the Region of Lombardy. These institutions appoint the Board of Directors, which is the strategy decision making body of the Foundation

Mission The decodification of the sequences of the human genome has opened a great gap between the capacity of accumulating scientific information and the possibility of translating these new discoveries into new therapies or improved diagnostic means. Italy as all European countries has an enormous need to optimize its research resources. Therefore, more "translational" research and a greater capacity to create "collaboration networks" among the different national and international research organizations. INGM comes to life with the aim of strengthening Italian biomedical research in these two key points for innovation.

INGM represents an opportunity for Italian biomedical research to constitute a technological platform (human immuno-proteomics) managed professionally and with strong connections with clinics so as to become an example of "translational" research. The success of the latter will soon translate scientific discoveries into improvement of health.

The presence among the founders of INGM of IRCCS Ospedale Maggiore of Milan facilitates the establishment of collaborations with the most important Italian IRCCS. As regards the collaboration with international institutes, we look for networks of common, equally shared programs characterized by high technological contents. In the private sector, the intent is to collaborate, on the basis of common interests, with leading Italian and international biotechnology companies, so as to create the bond between public and private research that represents the strength of technological innovation in the USA, but that has not been exploited to a great extent in Italy.

The initiative of the Ministry of Health for the creation of INGM underscores the need of Italian biomedical research to set up new structures so as to be competitive in the translation of basic research into technology and products capable of improving health. INGM will be an advanced research center, which will create a well-defined niche of activities in the field of human proteomics research. Through a logical and diversified network of public and private collaborations, this will lead to the identification of new therapeutic targets and to the development of new diagnostic means for neoplastic diseases and diseases with autoimmune etiology.

INGM Istituto Nazionale Genetica Molecolare c/o IRCCS Fondazione Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Padiglione ROMEO INVERNIZZI ed ENRICA PESSINA Via Francesco Sforza, 28 - 20122 Milano, Italy P.IVA 04175700964

Secretary Ms Manuela Bianco segreteria@ingm.it

Phone +39 02 00 660 211, +39 02 58 328 616 Fax +39 02 00 660 216, +39 02 58 439 349