User:Isabellawhiting19/Mitochondrial membrane transport protein/Bibliography

Annotated Bibliography
- "The outer membrane is porous and freely traversed by ions and small, uncharged molecules through pore-forming membrane proteins (porins), such as the voltage-dependent anion channel VDAC"

- Outer and inner membrane, outer freely permeable, inner on lock down

- "The closed vesicular structure of mitochondria is functionally essential for the chemiosmotic mechanism of oxidative phosphorylation (1), that is, a direct link between the electrochemical proton gradient across the inner membrane and the phosphorylation of ADP to ATP (oxidative phosphorylation)."

- mentions ATD and ADP translocase

- homo and heterodimeric transporters

- number of mitochondrial transporters vary by species (35 for yeast, 52 for humans)

- 53 mitochondrial carriers

- Several mitochondrial amino acid transporters have been identified, but some are still missing, **WE DO NOT HAVE EVERYTHING FIGURED OUT**

- The human mitochondrial ADP/ATP carrier AAC1 (SLC25A4) has three associated pathologies, which are quite different in nature:

- Mutations cause carnitine/acylcarnitine carrier deficiency, an autosomal recessive disorder characterized by severe, neonatal onset with cardiomyopathy or a milder phenotype with hypoglycemia, but no cardiomyopathy- FATTY ACID TRANSPORTER (find exact name)

- table of various mutations and what they cause