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Pulse therapy refers to the intermittent administration of drugs at a dose much greater than their normal therapeutic amount or concentration, in order to gain maximum therapeutic benefit as quickly as possible, while incurring as few side effects as possible; side effects which might otherwise be incurred following continuous exposure to the drug. Pulse therapy is used among multiple types of drug in order to treat various different conditions.

Corticosteroids
The first reported use of pulse therapy with corticosteroids is attributed to Samuel L. Kountz and Roy Cohn, who realised that a suprapharmacologic dose of methylprednisolone could reverse the acute rejection of a transplanted kidney.