User:JJD77/sandbox

Psychedelic microdosing is a practice to use sub-threshold doses (microdoses) of psychedelic drugs at regular intervals for extended periods of time in an attempt to improve creativity, boost physical energy level, emotional balance, increase performance on problems-solving tasks and to treat anxiety, depression and addiction. [1][2] The two most common psychedelic drugs used in microdosing are Lysergic acid diethylamide (LSD) and psilocybin (or mushrooms). In contrast to the recreational use of psychedelics, those who support microdosing stick to strict schedules, such as every 3 days, and do not observe any impairment in their normal functioning. In a study that evaluated the effects of three different doses on healthy human volunteers, it was concluded that the threshold dose of LSD that would effect normal functioning is 13 ug.  Doses lower than this are aonsidered appropriate for microdosing with LSD. A microdose is usually a tenth of an active dose of psychedelic drugs. This practice has become more widespread in the 21st century.[3] In 2018, a group of scientists at Imperial College London announced a self-blinding study recruiting volunteers across the globe via Internet, using questionnaires and games to evaluate psychological well-being and cognitive function effects of psychedelic microdosing.[4] A study published in 2019 tested the microdosing hypothesis by subjecting male and female Sprague Dawley rats to behavioral testing following the chronic, intermittent administration of low doses of the psychedelic N,N-dimethyltryptamine (DMT). The behavioral and cellular effects of this dosing regimen were distinct from those induced following a single high dose of the drug. The study found that chronic, intermittent, low doses of DMT produced an antidepressant-like phenotype and enhanced fear extinction learning without impacting working memory or social interaction. Additionally, male rats treated with DMT on this schedule gained a significant amount of body weight during the course of the study. Taken together, results suggest that psychedelic microdosing may alleviate symptoms of mood and anxiety disorders, though the potential hazards of this practice warrant further investigation.[5]

Tasks: - get rid of study published in 2019/no important information - add more general knowledge, too many specific sentences - Last two sentences are taken directly from an article- must be changed- plagiarized - maybe some history about it and why it is gaining popularity now

https://www.sciencedirect.com/science/article/abs/pii/S0955395919301161

https://pubs.acs.org/doi/pdf/10.1021%2Facschemneuro.8b00692

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211023

Stuff I'm adding:

'''schedule of drugs - every 3 days LSD - 1/10 of active dose, 13 ug is threshold dose for mystical effects psilocybin '''

microdoses are typically 1/10 to 1/20th of the active dose most common are LSD and psilocybin 

'''Most research to this point has been based on either anecdotal evidence or surveys. In one of the only double-blind, randomized studies, those given micro-doses of LSD did not perform better than those given the placebo on cognitive tasks. This study did not have any conclusive evidence on whether or not micro-dosing with LSD has any therapeutic effects for those suffering from anxiety or depressive disorders since all participants were healthy. '''

no cognitive benefit - study

Only review study https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-019-0308-4 Bold text