User:JLPhys2018/sandbox

= TRPV2: Transient Receptor Potential Cation Channel Subfamily V member 2 =

Background

 * Is a part of the TRP family TRPV (we can link it to the TRP page on wiki)
 * Gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius
 * Calcium permeability
 * Channel composition- I.e domains and motifs that makes up the channel
 * Kinetics of the channel
 * Is not activated by villinoid and acidic pH
 * Protein coding gene
 * Cell coding and response to harmful environments
 * May be involved in transduction of high-temperature heat responses in sensory ganglia

TRPV2 Interactions in Humans
- Brief Background on HIV - Gene vpr p15
 * HIV 1 Interaction

-Possible target for neuropathic pain
 * Clinical Relevance


 * Breast Cancer?


 * Role in Immunity


 * Brain diseases/function

Homology in Different Species
-Talk about homologous structures or systems that could be a clue of why there's similarity?
 * Protein structures among rabbits, chimpanzees, monkeys, etc.

Differences in Expression
-Broad expression in thymus, placenta, cerebellum, spleen -Broad expression in lymph nodes, spleen, prostate -Broad expression in adrenal glands, lungs
 * Mus musculus (house mouse)
 * Homo sapien (human)
 * Rattus norvegicus (Norway rat)