User:JW302/Tight junction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542074/ Main focus is blood brain barrier.

https://www.sciencedirect.com/science/article/pii/S0005273620301309?via%3Dihub Physiological function of JAM.

https://journals.physiology.org/doi/full/10.1152/physrev.00004.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Great source for anatomy of JAM and specialized functions.

https://www.mdpi.com/1422-0067/20/23/6020/htm The structure of JAMs and includes a great picture. I would like to use it.

Lead
Tight junctions, also known as occluding junctions or zonulae occludentes (singular, zonula occludens), are multiprotein junctional complexes whose canonical function is to prevent leakage of solutes and water and seals between the epithelial cells. They also play a critical role maintaining the structure and permisivity of endothelial cells. Tight junctions may also serve as leaky pathways by forming selective channels for small cations, anions, or water.

Article body

 * Junctional Adhesion Molecules (JAM) are part of the immunoglobulin superfamily. They have a molecular weight of ~40 to 48 kDa.
 * Their structure differs from that of the other integral membrane proteins in that they only have one transmembrane domain instead of four. [needs citation]
 * It helps to regulate the paracellular pathway function of tight junctions and is also involved in helping to maintain cell polarity.

Structure

 * The JAM link is wrong
 * No mention of PDZ domains
 * which would make more sense for when it talks about attaching to actin and cytoskeleton