User:Jakedreyer/sandbox

= TMEM186 = Transmembrane protein 186 (TMEM186, C16orf51) is a protein which in humans is encoded by the TMEM186 gene. It contains two exons, the longest of which encodes for a transmembrane protein expressed in the inner mitochondrial membrane. This protein is one of several assembly factors involved in the biogenesis of the mitochondrial respiratory chain Complex I.

Gene
TMEM186 is a protein consisting of 213 amino acids with a calculated molecular weight of 24.8 kDa. TMEM186 shows low tissue specificity and is expressed ubiquitously throughout a representative set of all major human organs and tissues. highest displays of expression exist in the kidneys, colon, and small intestine. It is located on the short arm of chromosome 16.

Protein
TMEM186 encodes for two helical transmembrane sites both 20 amino acids in length connected by a mitochondrial intermembrane region 2 amino acids in length. It was identified as an assembly factor in the biogenesis of teh first and largest of the mitochondrial respiratory complexes, Complex I. It is responsible for the stabilization and assembly of the MT-ND3 subunit along with TMEM126B.