User:Jaskaran.ghotra64/sandbox

Purine metabolism can have imbalances that can arise from harmful nucleotide triphosphosphates incorporating into DNA and RNA which further lead to genetic disturbances and mutations, and as a result, give rise to several types of diseases. Some of the diseases are:

1.    Severe Immunodeficiency by loss of adenosine deaminase.

2.    Hyperuricemia and Lesch-Nyhan syndrome by the loss of hypoxanthine-guanine phosphoribosyltransferase.

3.   Different types of cancer by an increase in the activities of enzymes like IMP dehydrogenase.